Chronic and Hereditary Pancreatitis

Elissa M. Downs; Sarah J Schwarzenberg

doi:10.1007/978-3-030-80068-0_35

Chronic and Hereditary Pancreatitis

Elissa M. Downs, Sarah J Schwarzenberg

Pediatric Gastroenterology, Hepatology & Nutrition

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Chronic pancreatitis is the continuation of progressive inflammatory damage to the pancreas, which can lead to endocrine and/or exocrine dysfunction. It is associated with significantly impaired quality of life in affected children, with intractable pain, missed days of school, and frequent emergency department or hospital evaluations. Diagnosis can be established with a combination of characteristic pancreatic pain, imaging findings, or endocrine and/or exocrine dysfunction. Careful assessment of risk factors, especially for hereditary factors, may assist with tailoring of interventions or determining prognosis. Management is complex and requires a multidisciplinary approach to optimize medical, endoscopic, and surgical therapy. Total pancreatectomy, islet autotransplant, could be considered with failure to respond to maximal therapies.

Original language	English (US)
Title of host publication	Textbook of Pediatric Gastroenterology, Hepatology and Nutrition
Subtitle of host publication	A Comprehensive Guide to Practice: Second Edition
Publisher	Springer International Publishing
Pages	461-471
Number of pages	11
ISBN (Electronic)	9783030800680
ISBN (Print)	9783030800673
DOIs	https://doi.org/10.1007/978-3-030-80068-0_35
State	Published - Jan 1 2021

Bibliographical note

Publisher Copyright:
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.

Keywords

CFTR (cystic fibrosis transmembrane receptor gene)
Chronic pancreatitis
ERCP (endoscopic retrograde cholangiopancreatography)
Exocrine pancreatic insufficiency
Hereditary pancreatitis
INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE)
MRCP (magnetic resonance cholangiopancreatography)
PERT (pancreatic enzyme replacement therapy)
PRSS1 (cationic trypsinogen gene)
TIGAR-O (Toxic/metabolic, Idiopathic, Genetic, Autoimmune, Recurrent/severe acute pancreatitis, and Obstructive risk factors)
TPIAT (total pancreatectomy, islet autotransplant)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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N2 - Chronic pancreatitis is the continuation of progressive inflammatory damage to the pancreas, which can lead to endocrine and/or exocrine dysfunction. It is associated with significantly impaired quality of life in affected children, with intractable pain, missed days of school, and frequent emergency department or hospital evaluations. Diagnosis can be established with a combination of characteristic pancreatic pain, imaging findings, or endocrine and/or exocrine dysfunction. Careful assessment of risk factors, especially for hereditary factors, may assist with tailoring of interventions or determining prognosis. Management is complex and requires a multidisciplinary approach to optimize medical, endoscopic, and surgical therapy. Total pancreatectomy, islet autotransplant, could be considered with failure to respond to maximal therapies.

AB - Chronic pancreatitis is the continuation of progressive inflammatory damage to the pancreas, which can lead to endocrine and/or exocrine dysfunction. It is associated with significantly impaired quality of life in affected children, with intractable pain, missed days of school, and frequent emergency department or hospital evaluations. Diagnosis can be established with a combination of characteristic pancreatic pain, imaging findings, or endocrine and/or exocrine dysfunction. Careful assessment of risk factors, especially for hereditary factors, may assist with tailoring of interventions or determining prognosis. Management is complex and requires a multidisciplinary approach to optimize medical, endoscopic, and surgical therapy. Total pancreatectomy, islet autotransplant, could be considered with failure to respond to maximal therapies.

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KW - Chronic pancreatitis

KW - ERCP (endoscopic retrograde cholangiopancreatography)

KW - Exocrine pancreatic insufficiency

KW - Hereditary pancreatitis

KW - INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE)

KW - MRCP (magnetic resonance cholangiopancreatography)

KW - PERT (pancreatic enzyme replacement therapy)

KW - PRSS1 (cationic trypsinogen gene)

KW - TIGAR-O (Toxic/metabolic, Idiopathic, Genetic, Autoimmune, Recurrent/severe acute pancreatitis, and Obstructive risk factors)

KW - TPIAT (total pancreatectomy, islet autotransplant)

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ER -

Chronic and Hereditary Pancreatitis

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

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