Choline is a full agonist in inducing activation of neuronal nitric oxide synthase via the muscarinic M1 receptor

Jason Lee Carriere, Esam E. El-Fakahany

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The present study was designed to characterize the interaction of choline with the M1 subtype of the muscarinic acetylcholine receptor. Using Chinese hamster ovary cells transfected with neuronal nitric oxide synthase and the cloned human M1 receptor (CHO hM1/nNOS cells), we investigated choline's effects on production of nitric oxide and elevation of intracellular [Ca2+]. Choline showed the properties of a full agonist in inducing the sustained plateau of increased intracellular [Ca2+], although it was only a partial agonist in inducing the larger, transient [Ca2+] peak. Choline was also found to act as a full agonist in stimulating the production of nitric oxide. These results have implications for efforts in the clinical treatment of dementia. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish (US)
Pages (from-to)82-89
Number of pages8
JournalPharmacology
Volume60
Issue number2
DOIs
StatePublished - Feb 2000

Keywords

  • Alzheimer's disease
  • Calcium signaling
  • Choline
  • M subtype
  • Muscarinic acetylcholine receptors
  • Neuronal nitric oxide synthase

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