Choline acetyltransferase activity is reduced in rat nucleus accumbens after unlimited access to self-administration of cocaine

Julie M. Wilson; Marilyn E. Carroll; Sylvie T. Lac; Linda M. DiStefano; Stephen J. Kish

doi:10.1016/0304-3940(94)90906-7

Choline acetyltransferase activity is reduced in rat nucleus accumbens after unlimited access to self-administration of cocaine

Julie M. Wilson, Marilyn E. Carroll, Sylvie T. Lac, Linda M. DiStefano, Stephen J. Kish

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Choline acetyltransferase (ChAT) activity was measured in discrete areas of rat brain after chronic, unlimited access to self-administration of cocaine. Mean activity of ChAT was reduced by approximately 30% in the nucleus accumbens, both on the last day of cocaine access and after 3 weeks cocaine withdrawal. These data suggest that chronic cocaine exposure might inhibit nucleus accumbens cholinergic neurones which could underlie some of the behavioral effects of cocaine.

Original language	English (US)
Pages (from-to)	29-32
Number of pages	4
Journal	Neuroscience Letters
Volume	180
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(94)90906-7
State	Published - Oct 10 1994

Keywords

Acetylcholine
Cocaine
Dopamine
Nucleus accumbens
Self-administration
Striatum

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10.1016/0304-3940(94)90906-7

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title = "Choline acetyltransferase activity is reduced in rat nucleus accumbens after unlimited access to self-administration of cocaine",

abstract = "Choline acetyltransferase (ChAT) activity was measured in discrete areas of rat brain after chronic, unlimited access to self-administration of cocaine. Mean activity of ChAT was reduced by approximately 30% in the nucleus accumbens, both on the last day of cocaine access and after 3 weeks cocaine withdrawal. These data suggest that chronic cocaine exposure might inhibit nucleus accumbens cholinergic neurones which could underlie some of the behavioral effects of cocaine.",

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AU - Carroll, Marilyn E.

AU - Lac, Sylvie T.

AU - DiStefano, Linda M.

AU - Kish, Stephen J.

PY - 1994/10/10

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N2 - Choline acetyltransferase (ChAT) activity was measured in discrete areas of rat brain after chronic, unlimited access to self-administration of cocaine. Mean activity of ChAT was reduced by approximately 30% in the nucleus accumbens, both on the last day of cocaine access and after 3 weeks cocaine withdrawal. These data suggest that chronic cocaine exposure might inhibit nucleus accumbens cholinergic neurones which could underlie some of the behavioral effects of cocaine.

AB - Choline acetyltransferase (ChAT) activity was measured in discrete areas of rat brain after chronic, unlimited access to self-administration of cocaine. Mean activity of ChAT was reduced by approximately 30% in the nucleus accumbens, both on the last day of cocaine access and after 3 weeks cocaine withdrawal. These data suggest that chronic cocaine exposure might inhibit nucleus accumbens cholinergic neurones which could underlie some of the behavioral effects of cocaine.

KW - Acetylcholine

KW - Cocaine

KW - Dopamine

KW - Nucleus accumbens

KW - Self-administration

KW - Striatum

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Choline acetyltransferase activity is reduced in rat nucleus accumbens after unlimited access to self-administration of cocaine

Abstract

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