Choline acetyltransferase activity is reduced in rat nucleus accumbens after unlimited access to self-administration of cocaine

Julie M. Wilson, Marilyn E. Carroll, Sylvie T. Lac, Linda M. DiStefano, Stephen J. Kish

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Choline acetyltransferase (ChAT) activity was measured in discrete areas of rat brain after chronic, unlimited access to self-administration of cocaine. Mean activity of ChAT was reduced by approximately 30% in the nucleus accumbens, both on the last day of cocaine access and after 3 weeks cocaine withdrawal. These data suggest that chronic cocaine exposure might inhibit nucleus accumbens cholinergic neurones which could underlie some of the behavioral effects of cocaine.

Original languageEnglish (US)
Pages (from-to)29-32
Number of pages4
JournalNeuroscience Letters
Volume180
Issue number1
DOIs
StatePublished - Oct 10 1994

Bibliographical note

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

  • Acetylcholine
  • Cocaine
  • Dopamine
  • Nucleus accumbens
  • Self-administration
  • Striatum

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