Cholesterol-A janus-faced molecule in the central nervous system

W. Gibson Wood, U. Igbavboa, G. P. Eckert, W. E. Müller

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Abstract

Understanding the role of cholesterol in normal brain function and its involvement in specific neurodegenerative diseases has attracted considerable attention. One general observation is that there are notable differences in the brain cholesterol properties and dynamics as compared with cholesterol outside of the brain. In addition, much of what is known of brain cholesterol is based on studies focusing on the total or bulk amount of cholesterol; however, it is becoming increasingly recognized that cholesterol domains may provide greater insight into the cellular function of cholesterol. This chapter, therefore, examines the role of cholesterol in brain, compares the properties and dynamics of brain and peripheral cholesterol, and describes cholesterol domains and the contribution of cholesterol to brain pathophysiology, with an emphasis on Alzheimer's disease (AD). Attention is also directed at the participation of other compounds in the brain cholesterol biosynthetic pathway, namely isoprenoids and the cholesterol metabolites, oxysterols.

Original languageEnglish (US)
Title of host publicationHandbook of Neurochemistry and Molecular Neurobiology
Subtitle of host publicationNeural Membranes and Transport
PublisherSpringer US
Pages151-170
Number of pages20
ISBN (Print)9780387303468
DOIs
StatePublished - Dec 1 2007

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