Cholestasis in Preterm Infants

Katie Satrom, Glenn R Gourley

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Cholestasis in preterm infants has a multifactorial etiology. Risk factors include degree of prematurity, lack of enteral feeding, intestinal injury, prolonged use of parenteral nutrition (PN), and sepsis. Soy-based parenteral lipid emulsions have been implicated in the pathophysiology of PN-associated liver injury. Inflammation plays an important role. Medical therapies are used; however, their effects have not consistently proven effective. Evaluation of cholestasis involves laboratory work; direct bilirubin levels are used for diagnosis and trending. Adverse outcomes include risk for hepatobiliary dysfunction, irreversible liver failure, and death. Early enteral feedings as tolerated is the best way to prevent and manage cholestasis.

Original languageEnglish (US)
Pages (from-to)355-373
Number of pages19
JournalClinics in Perinatology
Volume43
Issue number2
DOIs
StatePublished - Jun 1 2016

Keywords

  • Cholestasis
  • Direct hyperbilirubinemia
  • Intestinal failure
  • Jaundice
  • Parenteral nutrition associated liver disease (PNALD)
  • Preterm infant
  • Sepsis
  • Short bowel syndrome (SBS)

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