Cholecystokinin-octapeptide suppresses stress-induced eating by inducing hyperglycemia

Allen S. Levine; John E. Morley

doi:10.1016/0167-0115(81)90017-3

Cholecystokinin-octapeptide suppresses stress-induced eating by inducing hyperglycemia

Allen S. Levine, John E. Morley

Medicine - Administration

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Abstract

Intracerebroventricular administration of cholecystokinin-octapeptide (CCK-8) in unanesthetized, unrestrained rats suppressed stress-induced eating and produced hyperglycemia. Prior adrenalectomy markedly reduced the hyperglycemic effect of intraventricular CCK-8 and also decreased the suppressive effect of CCK-8 on stress-induced eating. Our data are compatible with the anorectic effect of CCK-8 being secondary to the hyperglycemia it produces.

Original language	English (US)
Pages (from-to)	353-357
Number of pages	5
Journal	Regulatory Peptides
Volume	2
Issue number	6
DOIs	https://doi.org/10.1016/0167-0115(81)90017-3
State	Published - Nov 1981

Keywords

adrenalectomy
appetite
cholecystokinin-octapeptide

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10.1016/0167-0115(81)90017-3

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abstract = "Intracerebroventricular administration of cholecystokinin-octapeptide (CCK-8) in unanesthetized, unrestrained rats suppressed stress-induced eating and produced hyperglycemia. Prior adrenalectomy markedly reduced the hyperglycemic effect of intraventricular CCK-8 and also decreased the suppressive effect of CCK-8 on stress-induced eating. Our data are compatible with the anorectic effect of CCK-8 being secondary to the hyperglycemia it produces.",

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AU - Morley, John E.

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AB - Intracerebroventricular administration of cholecystokinin-octapeptide (CCK-8) in unanesthetized, unrestrained rats suppressed stress-induced eating and produced hyperglycemia. Prior adrenalectomy markedly reduced the hyperglycemic effect of intraventricular CCK-8 and also decreased the suppressive effect of CCK-8 on stress-induced eating. Our data are compatible with the anorectic effect of CCK-8 being secondary to the hyperglycemia it produces.

KW - adrenalectomy

KW - appetite

KW - cholecystokinin-octapeptide

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Cholecystokinin-octapeptide suppresses stress-induced eating by inducing hyperglycemia

Abstract

Keywords

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