Cholecystokinin-octapeptide suppresses stress-induced eating by inducing hyperglycemia

Allen S. Levine, John E. Morley

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Intracerebroventricular administration of cholecystokinin-octapeptide (CCK-8) in unanesthetized, unrestrained rats suppressed stress-induced eating and produced hyperglycemia. Prior adrenalectomy markedly reduced the hyperglycemic effect of intraventricular CCK-8 and also decreased the suppressive effect of CCK-8 on stress-induced eating. Our data are compatible with the anorectic effect of CCK-8 being secondary to the hyperglycemia it produces.

Original languageEnglish (US)
Pages (from-to)353-357
Number of pages5
JournalRegulatory Peptides
Volume2
Issue number6
DOIs
StatePublished - Nov 1981

Keywords

  • adrenalectomy
  • appetite
  • cholecystokinin-octapeptide

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