Cholangiopathies and the noncoding revolution

Sergio Gradilone, Nicola Brunetti-Pierri, Pasquale Piccolo

Research output: Contribution to journalReview articlepeer-review


Purpose of reviewNoncoding RNAs (ncRNAs), including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) among others, have attracted a great deal of attention for their potential role as master regulators of gene expression and as therapeutic targets. This review focuses on recent advances on the role of ncRNAs in the pathogenesis, diagnosis and treatment of diseases of the cholangiocytes (i.e. cholangiopathies).Recent findingsIn the recent years, there has been an exponential growth in the knowledge on ncRNAs and their role in cholangiopathies, particularly cholangiocarcinoma.SummaryAlthough several studies focused on miRNAs as noninvasive biomarkers for diagnosis and staging, several studies also highlighted their functions and provided new insights into disease mechanisms.

Original languageEnglish (US)
Pages (from-to)128-135
Number of pages8
JournalCurrent opinion in gastroenterology
Issue number2
StatePublished - Mar 1 2022

Bibliographical note

Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.


  • biliary diseases
  • cholangiocarcinoma
  • cholangiopathies
  • microRNA

PubMed: MeSH publication types

  • Journal Article
  • Review


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