Cholangiocytes’ primary cilia regulate DNA damage response and repair

Keyphrases

• Primary Cilia 100%
• DNA Damage Response 100%
• Cholangiocytes 100%
• DNA Damage Repair 100%
• DNA Damage 80%
• Cilia 60%
• H2AX 60%
• DNA Repair Pathways 40%
• Cholangiocarcinoma 40%
• Irradiation 40%
• Comet Assay 40%
• Deciliation 40%
• IFT88 40%
• Novel Therapeutics 20%
• Liver 20%
• Cisplatin 20%
• Knock-in Mouse Model 20%
• DNA Repair Enzymes 20%
• Cell Survival 20%
• DNA Repair 20%
• Dysregulation 20%
• PARP Inhibitor (PARPi) 20%
• Tumor Suppress 20%
• Protective Behavior 20%
• Cell Cycle Progression 20%
• Progression Rate 20%
• Albumin 20%
• Cre-mediated Recombination 20%
• In Vivo Model 20%
• Checkpoint Kinase 1 (CHK1) 20%
• Colocalization 20%
• S-phase Arrest 20%
• Genotoxic Agents 20%
• Liver-specific 20%
• RAD51 20%
• Apoptosis Rate 20%
• Methyl Methanesulfonate 20%
• P21 Protein 20%
• Reduced Survival 20%
• Rad3 20%
• Ataxia Telangiectasia mutated 20%
• Ciliary 20%
• SiRNA Knockdown 20%
• Ataxia Telangiectasia 20%
• Chk2 20%
• Mutated p53 20%
• Ciliated Cells 20%
• Histone H2AX Phosphorylation 20%
• KIF3A 20%
• Protein p53 20%
• Critical DNA 20%
• CRISPR Knockout 20%
• DNA Repair Capacity 20%
• IFT20 20%

Medicine and Dentistry

• DNA Repair 100%
• DNA Damage Response 100%
• Primary Cilium 100%
• Cholangiocyte 100%
• DNA Damage 60%
• Cilium 60%
• Cholangiocarcinoma 40%
• Comet Assay 40%
• Base 20%
• Cell Survival 20%
• Neoplasm 20%
• Protein P53 20%
• S Phase 20%
• Clustered Regularly Interspaced Short Palindromic Repeat 20%
• Programmed Cell Death 20%
• Short Hairpin RNA 20%
• Cell Cycle Progression 20%
• Albumin 20%
• Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase 1 20%
• Protein P21 20%
• Knockout Model 20%
• ATM Protein 20%
• DNA Repair Protein 20%
• Mesylic Acid Methyl Ester 20%
• Cre-Lox Recombination 20%
• ATR Protein 20%
• Cell Line 20%
• Cisplatin 20%

Immunology and Microbiology

• Primary Cilium 100%
• DNA Damage Response 100%
• Cholangiocyte 100%
• DNA Repair 100%
• DNA Damage 50%
• Cilium 50%
• Comet Assay 33%
• Ataxia Telangiectasia 33%
• Cell Line 16%
• Cell Survival 16%
• Cell Cycle Progression 16%
• Apoptosis Rate 16%
• Knockout Model 16%
• Clustered Regularly Interspaced Short Palindromic Repeat 16%
• P53 16%
• Albumin 16%