“CHOICES”: An acronym to aid in delineating potential causes of non-metabolic, non-infectious acute toxic leukoencephalopathy

Research output: Contribution to journalReview article

Abstract

Purpose: To describe non-metabolic, non-infectious etiologies of acute toxic leukoencephalopathy (ATL) on DWI MRI, and provide a useful acronym to remember them. Material and Methods: Our PACS archive was reviewed, yielding 185 patients with suspected ATL per MRI reports and clinical follow up; infectious or metabolic causes were excluded. Result/Discussion: The 87 included non-infectious, non-metabolic ATL patients' etiologies are represented by the acronym 'CHOICES': chemotherapy ('C',n = 34); heroin-induced ('H',n = 6), opioid analogues ('O',n = 14); immunosuppressant ('I',n = 11) or imidazole (n = 2); cocaine ('C',n = 1); environmental or ethanol abuse ('E',n = 5), splenial lesions ('S',n = 9), and 'other' (n = 5). Conclusion: The “CHOICES” acronym delineates various toxic etiologies of ATL.

Original languageEnglish (US)
Pages (from-to)243-257
Number of pages15
JournalEuropean Journal of Radiology Open
Volume6
DOIs
StatePublished - 2019

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Leukoencephalopathies
Poisons
Heroin
Immunosuppressive Agents
Cocaine
Opioid Analgesics
Ethanol
Drug Therapy

Keywords

  • Acute toxic leukoencephalopathy
  • Diffusion-Weighted imaging
  • Periventricular white matter

PubMed: MeSH publication types

  • Journal Article
  • Review

Cite this

@article{8bf943af10304f848afb0483686a5167,
title = "“CHOICES”: An acronym to aid in delineating potential causes of non-metabolic, non-infectious acute toxic leukoencephalopathy",
abstract = "Purpose: To describe non-metabolic, non-infectious etiologies of acute toxic leukoencephalopathy (ATL) on DWI MRI, and provide a useful acronym to remember them. Material and Methods: Our PACS archive was reviewed, yielding 185 patients with suspected ATL per MRI reports and clinical follow up; infectious or metabolic causes were excluded. Result/Discussion: The 87 included non-infectious, non-metabolic ATL patients' etiologies are represented by the acronym 'CHOICES': chemotherapy ('C',n = 34); heroin-induced ('H',n = 6), opioid analogues ('O',n = 14); immunosuppressant ('I',n = 11) or imidazole (n = 2); cocaine ('C',n = 1); environmental or ethanol abuse ('E',n = 5), splenial lesions ('S',n = 9), and 'other' (n = 5). Conclusion: The “CHOICES” acronym delineates various toxic etiologies of ATL.",
keywords = "Acute toxic leukoencephalopathy, Diffusion-Weighted imaging, Periventricular white matter",
author = "Yasemin Koksel and Can Ozutemiz and Rykken, {Jeffrey B} and Ott, {Frederick W} and Zuzan Cayci and Mark Oswood and McKinney, {Alexander M}",
year = "2019",
doi = "10.1016/j.ejro.2019.06.005",
language = "English (US)",
volume = "6",
pages = "243--257",
journal = "European Journal of Radiology Open",
issn = "2352-0477",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - “CHOICES”

T2 - An acronym to aid in delineating potential causes of non-metabolic, non-infectious acute toxic leukoencephalopathy

AU - Koksel, Yasemin

AU - Ozutemiz, Can

AU - Rykken, Jeffrey B

AU - Ott, Frederick W

AU - Cayci, Zuzan

AU - Oswood, Mark

AU - McKinney, Alexander M

PY - 2019

Y1 - 2019

N2 - Purpose: To describe non-metabolic, non-infectious etiologies of acute toxic leukoencephalopathy (ATL) on DWI MRI, and provide a useful acronym to remember them. Material and Methods: Our PACS archive was reviewed, yielding 185 patients with suspected ATL per MRI reports and clinical follow up; infectious or metabolic causes were excluded. Result/Discussion: The 87 included non-infectious, non-metabolic ATL patients' etiologies are represented by the acronym 'CHOICES': chemotherapy ('C',n = 34); heroin-induced ('H',n = 6), opioid analogues ('O',n = 14); immunosuppressant ('I',n = 11) or imidazole (n = 2); cocaine ('C',n = 1); environmental or ethanol abuse ('E',n = 5), splenial lesions ('S',n = 9), and 'other' (n = 5). Conclusion: The “CHOICES” acronym delineates various toxic etiologies of ATL.

AB - Purpose: To describe non-metabolic, non-infectious etiologies of acute toxic leukoencephalopathy (ATL) on DWI MRI, and provide a useful acronym to remember them. Material and Methods: Our PACS archive was reviewed, yielding 185 patients with suspected ATL per MRI reports and clinical follow up; infectious or metabolic causes were excluded. Result/Discussion: The 87 included non-infectious, non-metabolic ATL patients' etiologies are represented by the acronym 'CHOICES': chemotherapy ('C',n = 34); heroin-induced ('H',n = 6), opioid analogues ('O',n = 14); immunosuppressant ('I',n = 11) or imidazole (n = 2); cocaine ('C',n = 1); environmental or ethanol abuse ('E',n = 5), splenial lesions ('S',n = 9), and 'other' (n = 5). Conclusion: The “CHOICES” acronym delineates various toxic etiologies of ATL.

KW - Acute toxic leukoencephalopathy

KW - Diffusion-Weighted imaging

KW - Periventricular white matter

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