Chloramphenicol: Effects on mouse myeloma cells in tissue culture

Boyd K. Hartman; Olive S. Pettengill; George D. Sorenson

doi:10.1126/science.165.3890.297

Chloramphenicol: Effects on mouse myeloma cells in tissue culture

Boyd K. Hartman, Olive S. Pettengill, George D. Sorenson

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

Within 36 hours of being administered, chloramphenicol (50 micrograms per milliliter) inhibits by 50 percent the rate of protein synthesis in mouse myeloma cells grown in suspension culture. Although there is a decrease in the amount of globulin synthesized, the rate of synthesis per cell is unchanged; the observed decrease is traced to the inhibition of cell proliferation caused by chloramphenicol.

Original language	English (US)
Pages (from-to)	297-298
Number of pages	2
Journal	Science
Volume	165
Issue number	3890
DOIs	https://doi.org/10.1126/science.165.3890.297
State	Published - Jan 1 1969

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title = "Chloramphenicol: Effects on mouse myeloma cells in tissue culture",

abstract = "Within 36 hours of being administered, chloramphenicol (50 micrograms per milliliter) inhibits by 50 percent the rate of protein synthesis in mouse myeloma cells grown in suspension culture. Although there is a decrease in the amount of globulin synthesized, the rate of synthesis per cell is unchanged; the observed decrease is traced to the inhibition of cell proliferation caused by chloramphenicol.",

author = "Hartman, {Boyd K.} and Pettengill, {Olive S.} and Sorenson, {George D.}",

year = "1969",

month = jan,

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doi = "10.1126/science.165.3890.297",

language = "English (US)",

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pages = "297--298",

journal = "Science",

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TY - JOUR

T1 - Chloramphenicol

T2 - Effects on mouse myeloma cells in tissue culture

AU - Hartman, Boyd K.

AU - Pettengill, Olive S.

AU - Sorenson, George D.

PY - 1969/1/1

Y1 - 1969/1/1

N2 - Within 36 hours of being administered, chloramphenicol (50 micrograms per milliliter) inhibits by 50 percent the rate of protein synthesis in mouse myeloma cells grown in suspension culture. Although there is a decrease in the amount of globulin synthesized, the rate of synthesis per cell is unchanged; the observed decrease is traced to the inhibition of cell proliferation caused by chloramphenicol.

AB - Within 36 hours of being administered, chloramphenicol (50 micrograms per milliliter) inhibits by 50 percent the rate of protein synthesis in mouse myeloma cells grown in suspension culture. Although there is a decrease in the amount of globulin synthesized, the rate of synthesis per cell is unchanged; the observed decrease is traced to the inhibition of cell proliferation caused by chloramphenicol.

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Chloramphenicol: Effects on mouse myeloma cells in tissue culture

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