Chitin or chitin-like glycans as targets for late-term cancer chemoprevention

Lee W. Wattenberg, Steven Patterson, Jennifer D. Antonides

Research output: Contribution to journalComment/debate

5 Citations (Scopus)

Abstract

A consistent observation in studies of carcinogenesis is that some glycans are expressed differently in cancer cells than in normal cells. A well-known example is the aberrant β1-6 N-acetyl-D-glucosamine branching associated with metastasis and poor prognosis in many cancers. This commentary proposes that, although not found in normal mammalian cells, a chitin (β-1,4-linked N-acetyl-D-glucosamine) or a chitin-like polysaccharide (e.g., hyaluronan) may exist as a cancer-associated glycan, which can be targeted by the novel pyrimidine nucleotide derivative SP-1015 (designed as a chitin synthase inhibitor). Preliminary chemoprevention data of our group showed SP-1015 in the diet can inhibit benzo(a)pyrene-induced neoplasia in the forestomach of female A/J mice, and, of importance, this activity occurred at late stages in carcinogenesis. While no effect was seen in the murine lung, this may be due to the low bioavailability of the compound. A different route of administration (e.g. inhalation of an aerosol) may have potential to inhibit pulmonary carcinogenesis. We hypothesize that inhibitors of chitin or chitin-like glycan formation may be effective chemopreventive agents and suggest that further work is needed to study these novel targets for cancer prevention.

Original languageEnglish (US)
Pages (from-to)1519-1522
Number of pages4
JournalCancer Prevention Research
Volume3
Issue number12
DOIs
StatePublished - Dec 1 2010

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Chitin
Chemoprevention
Polysaccharides
Carcinogenesis
Acetylglucosamine
Neoplasms
Chitin Synthase
Inhalation Administration
Pyrimidine Nucleotides
Lung
Benzo(a)pyrene
Hyaluronic Acid
Aerosols
Biological Availability
Observation
Neoplasm Metastasis
Diet

Cite this

Chitin or chitin-like glycans as targets for late-term cancer chemoprevention. / Wattenberg, Lee W.; Patterson, Steven; Antonides, Jennifer D.

In: Cancer Prevention Research, Vol. 3, No. 12, 01.12.2010, p. 1519-1522.

Research output: Contribution to journalComment/debate

Wattenberg, Lee W. ; Patterson, Steven ; Antonides, Jennifer D. / Chitin or chitin-like glycans as targets for late-term cancer chemoprevention. In: Cancer Prevention Research. 2010 ; Vol. 3, No. 12. pp. 1519-1522.
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