Chiral Synthesis and Enzymatic Resolution of (S)-(-)Piperazine-2-Carboxylic Acid Using Enzyme Alcalase

Guosheng Wu; Hua Zhao; Robert G. Luo; Dean Wei; Sanjay V. Malhotra

Chiral Synthesis and Enzymatic Resolution of (S)-(-)Piperazine-2-Carboxylic Acid Using Enzyme Alcalase

Guosheng Wu, Hua Zhao, Robert G. Luo, Dean Wei, Sanjay V. Malhotra

Research output: Contribution to journal › Article › peer-review

Abstract

Enantiomerically pure (S)-piperazine-2-carboxylic acid was synthesized by kinetic resolution of methyl-4-(tert-butyroxycarbonyl)-piperazine-2-carboxylate using a low cost enzyme alcalase.

Original language	English (US)
Pages (from-to)	343-345
Number of pages	3
Journal	Enantiomer
Volume	6
Issue number	6
State	Published - 2001
Externally published	Yes

Keywords

(S)-piperazine-2-carboxylic acid
Chiral synthesis
Enzymatic resolution
Unnatural amino acid

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title = "Chiral Synthesis and Enzymatic Resolution of (S)-(-)Piperazine-2-Carboxylic Acid Using Enzyme Alcalase",

abstract = "Enantiomerically pure (S)-piperazine-2-carboxylic acid was synthesized by kinetic resolution of methyl-4-(tert-butyroxycarbonyl)-piperazine-2-carboxylate using a low cost enzyme alcalase.",

keywords = "(S)-piperazine-2-carboxylic acid, Chiral synthesis, Enzymatic resolution, Unnatural amino acid",

author = "Guosheng Wu and Hua Zhao and Luo, {Robert G.} and Dean Wei and Malhotra, {Sanjay V.}",

year = "2001",

language = "English (US)",

volume = "6",

pages = "343--345",

journal = "Enantiomer",

issn = "1024-2430",

publisher = "Taylor and Francis Ltd.",

number = "6",

}

TY - JOUR

T1 - Chiral Synthesis and Enzymatic Resolution of (S)-(-)Piperazine-2-Carboxylic Acid Using Enzyme Alcalase

AU - Wu, Guosheng

AU - Zhao, Hua

AU - Luo, Robert G.

AU - Wei, Dean

AU - Malhotra, Sanjay V.

PY - 2001

Y1 - 2001

N2 - Enantiomerically pure (S)-piperazine-2-carboxylic acid was synthesized by kinetic resolution of methyl-4-(tert-butyroxycarbonyl)-piperazine-2-carboxylate using a low cost enzyme alcalase.

AB - Enantiomerically pure (S)-piperazine-2-carboxylic acid was synthesized by kinetic resolution of methyl-4-(tert-butyroxycarbonyl)-piperazine-2-carboxylate using a low cost enzyme alcalase.

KW - (S)-piperazine-2-carboxylic acid

KW - Chiral synthesis

KW - Enzymatic resolution

KW - Unnatural amino acid

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UR - http://www.scopus.com/inward/citedby.url?scp=0035754295&partnerID=8YFLogxK

M3 - Article

C2 - 11958341

AN - SCOPUS:0035754295

SN - 1024-2430

VL - 6

SP - 343

EP - 345

JO - Enantiomer

JF - Enantiomer

IS - 6

ER -

Chiral Synthesis and Enzymatic Resolution of (S)-(-)Piperazine-2-Carboxylic Acid Using Enzyme Alcalase

Abstract

Keywords

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