Abstract
We report a stereoselective total synthesis of a natural product, phomonol, from readily available D-aspartic acid. The key steps include Wittig olefination, Sharpless asymmetric dihydroxylation, Grignard addition, diastereoselective reductive etherification and Wacker oxidation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 445-450 |
| Number of pages | 6 |
| Journal | Synthetic Communications |
| Volume | 52 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2022 |
Bibliographical note
Funding Information:SY and RD are thankful to SERB for the financial support, [grant no-SERB/EMR/2016/4812], and fellowship, respectively.
Publisher Copyright:
© 2022 Taylor & Francis Group, LLC.
Keywords
- Total synthesis
- hiral pool
- natural products
- reductive etherification
- sharpless asymmetric dihydroxylation