Chiral pool approach to the total synthesis of phomonol

Ravikrishna Dada, Srinivasarao Yaragorla

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

We report a stereoselective total synthesis of a natural product, phomonol, from readily available D-aspartic acid. The key steps include Wittig olefination, Sharpless asymmetric dihydroxylation, Grignard addition, diastereoselective reductive etherification and Wacker oxidation.

Original languageEnglish (US)
Pages (from-to)445-450
Number of pages6
JournalSynthetic Communications
Volume52
Issue number3
DOIs
StatePublished - 2022

Bibliographical note

Funding Information:
SY and RD are thankful to SERB for the financial support, [grant no-SERB/EMR/2016/4812], and fellowship, respectively.

Publisher Copyright:
© 2022 Taylor & Francis Group, LLC.

Keywords

  • Total synthesis
  • hiral pool
  • natural products
  • reductive etherification
  • sharpless asymmetric dihydroxylation

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