Chiral N-phosphonyl imine chemistry: Asymmetric aza-Henry reaction

Adiseshu Kattuboina, Parminder Kaur, Teng Ai, Guigen Li

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


A series of chiral N-phosphonyl imines have been synthesized and utilized successfully in asymmetric aza-Henry reaction. The chiral auxiliary was optimized for this reaction by varying different R groups on the nitrogen atoms. The reaction is convenient to perform to give excellent yields and good diastereoselectivities. The absolute stereochemistry was unambiguously determined by converting a resulting vicinal nitroamine into its N-Boc derivative which serves as a known compound.

Original languageEnglish (US)
Pages (from-to)216-223
Number of pages8
JournalChemical Biology and Drug Design
Issue number3
StatePublished - Mar 2008


  • Chiral N-phosphonyl imines
  • Chiral phosphoramide
  • aza-Henry reaction


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