Chimeric Humanized Vasculature and Blood: The Intersection of Science and Ethics

Daniel J. Garry; Arthur L. Caplan; Mary G. Garry

doi:10.1016/j.stemcr.2020.03.016

Chimeric Humanized Vasculature and Blood: The Intersection of Science and Ethics

Daniel J. Garry, Arthur L. Caplan, Mary G. Garry

Medicine - Cardiology Division

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

The only curative therapy for diseases such as organ failure is orthotopic organ transplantation. Organ transplantation has been limited due to the shortage of donor organs. The huge disparity between those who need and those who receive transplantation therapy drives the pursuit of alternative treatments. Therefore, novel therapies are warranted. Recent studies support the feasibility of generating human-porcine chimeras that one day would provide humanized vasculature and blood for transplantation and serve as important research models. The ethical issues they raise require open discussion and dialog lest promising lines of inquiry flounder due to unfounded fears or compromised public trust.

Original language	English (US)
Pages (from-to)	538-540
Number of pages	3
Journal	Stem Cell Reports
Volume	14
Issue number	4
DOIs	https://doi.org/10.1016/j.stemcr.2020.03.016
State	Published - Apr 14 2020

Bibliographical note

Funding Information:
D.J.G. is supported by grants from RMM, DOD, and the Lillehei Family Foundation. M.G.G. is supported by grant funding from the DOD. D.J.G. and M.G.G. are co-founders of NorthStar Genomics. A.L.C. has no conflicts of interest.

Funding Information:
D.J.G. is supported by grants from RMM , DOD , and the Lillehei Family Foundation . M.G.G. is supported by grant funding from the DOD . D.J.G. and M.G.G. are co-founders of NorthStar Genomics. A.L.C. has no conflicts of interest.

Publisher Copyright:
© 2020 The Authors

Keywords

Etv2
chimeras
complementation
ethics
human
pig

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.stemcr.2020.03.016

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title = "Chimeric Humanized Vasculature and Blood: The Intersection of Science and Ethics",

abstract = "The only curative therapy for diseases such as organ failure is orthotopic organ transplantation. Organ transplantation has been limited due to the shortage of donor organs. The huge disparity between those who need and those who receive transplantation therapy drives the pursuit of alternative treatments. Therefore, novel therapies are warranted. Recent studies support the feasibility of generating human-porcine chimeras that one day would provide humanized vasculature and blood for transplantation and serve as important research models. The ethical issues they raise require open discussion and dialog lest promising lines of inquiry flounder due to unfounded fears or compromised public trust.",

keywords = "Etv2, chimeras, complementation, ethics, human, pig",

author = "Garry, {Daniel J.} and Caplan, {Arthur L.} and Garry, {Mary G.}",

note = "Funding Information: D.J.G. is supported by grants from RMM, DOD, and the Lillehei Family Foundation. M.G.G. is supported by grant funding from the DOD. D.J.G. and M.G.G. are co-founders of NorthStar Genomics. A.L.C. has no conflicts of interest. Funding Information: D.J.G. is supported by grants from RMM , DOD , and the Lillehei Family Foundation . M.G.G. is supported by grant funding from the DOD . D.J.G. and M.G.G. are co-founders of NorthStar Genomics. A.L.C. has no conflicts of interest. Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

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language = "English (US)",

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T2 - The Intersection of Science and Ethics

AU - Garry, Daniel J.

AU - Caplan, Arthur L.

AU - Garry, Mary G.

N1 - Funding Information: D.J.G. is supported by grants from RMM, DOD, and the Lillehei Family Foundation. M.G.G. is supported by grant funding from the DOD. D.J.G. and M.G.G. are co-founders of NorthStar Genomics. A.L.C. has no conflicts of interest. Funding Information: D.J.G. is supported by grants from RMM , DOD , and the Lillehei Family Foundation . M.G.G. is supported by grant funding from the DOD . D.J.G. and M.G.G. are co-founders of NorthStar Genomics. A.L.C. has no conflicts of interest. Publisher Copyright: © 2020 The Authors

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N2 - The only curative therapy for diseases such as organ failure is orthotopic organ transplantation. Organ transplantation has been limited due to the shortage of donor organs. The huge disparity between those who need and those who receive transplantation therapy drives the pursuit of alternative treatments. Therefore, novel therapies are warranted. Recent studies support the feasibility of generating human-porcine chimeras that one day would provide humanized vasculature and blood for transplantation and serve as important research models. The ethical issues they raise require open discussion and dialog lest promising lines of inquiry flounder due to unfounded fears or compromised public trust.

AB - The only curative therapy for diseases such as organ failure is orthotopic organ transplantation. Organ transplantation has been limited due to the shortage of donor organs. The huge disparity between those who need and those who receive transplantation therapy drives the pursuit of alternative treatments. Therefore, novel therapies are warranted. Recent studies support the feasibility of generating human-porcine chimeras that one day would provide humanized vasculature and blood for transplantation and serve as important research models. The ethical issues they raise require open discussion and dialog lest promising lines of inquiry flounder due to unfounded fears or compromised public trust.

KW - Etv2

KW - chimeras

KW - complementation

KW - ethics

KW - human

KW - pig

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JO - Stem Cell Reports

JF - Stem Cell Reports

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Chimeric Humanized Vasculature and Blood: The Intersection of Science and Ethics

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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