Children with Chronic Hepatitis B in the United States and Canada

Kathleen B. Schwarz, Yona Keich Cloonan, Simon C. Ling, Karen F. Murray, Norberto Rodriguez-Baez, Sarah Jane Schwarzenberg, Jeffrey Teckman, Lilia Ganova-Raeva, Philip Rosenthal, Hepatitis B Research Network

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

OBJECTIVES: To test the hypothesis that children with chronic hepatitis B living in the US and Canada would have international origins and characteristic hepatitis B virus (HBV) genotypes and laboratory profiles.

STUDY DESIGN: Clinical characteristics of children enrolled in the Hepatitis B Research Network were collected from 7 US and Canadian centers.

RESULTS: Children (n = 343) with an age range of 1.0-17.8 years were enrolled; 78% of the children were Asian, 55% were adopted, and 97% had international origins with either the child or a parent born in 1 of 31 countries. The majority had HBV genotype B (43%) or C (32%), and the remainder had genotype A (5%), D (16%), E (4%), or multiple (<1%). Children with genotype B or C were more likely to be Asian (98% and 96%), more consistently hepatitis B envelope antigen positive (95% and 82%), had higher median HBV DNA levels (8.2 and 8.3 log10 IU/mL), and less frequently had elevated alanine aminotransferase values (43% and 57%) compared with children with other genotypes. The percentage of hepatitis B envelope antigen positivity and of those with HBV DNA ≥6 log₁₀ IU/mL declined with age.

CONCLUSIONS: The majority of children in the Hepatitis B Research Network have HBV genotypes that reflect their international origins. Clinical and laboratory data differ substantially by patient age and HBV genotype. Use of these data can help drive the development of optimal strategies to manage and treat children with chronic hepatitis B.

Original languageEnglish (US)
Pages (from-to)1287-1294.e2
JournalThe Journal of pediatrics
Volume167
Issue number6
DOIs
StatePublished - Dec 1 2015

Fingerprint

Chronic Hepatitis B
Canada
Hepatitis B virus
Genotype
Hepatitis B Antigens
Hepatitis B
DNA
Alanine Transaminase
Research

Cite this

Schwarz, K. B., Cloonan, Y. K., Ling, S. C., Murray, K. F., Rodriguez-Baez, N., Schwarzenberg, S. J., ... Hepatitis B Research Network (2015). Children with Chronic Hepatitis B in the United States and Canada. The Journal of pediatrics, 167(6), 1287-1294.e2. https://doi.org/10.1016/j.jpeds.2015.08.021

Children with Chronic Hepatitis B in the United States and Canada. / Schwarz, Kathleen B.; Cloonan, Yona Keich; Ling, Simon C.; Murray, Karen F.; Rodriguez-Baez, Norberto; Schwarzenberg, Sarah Jane; Teckman, Jeffrey; Ganova-Raeva, Lilia; Rosenthal, Philip; Hepatitis B Research Network.

In: The Journal of pediatrics, Vol. 167, No. 6, 01.12.2015, p. 1287-1294.e2.

Research output: Contribution to journalArticle

Schwarz, KB, Cloonan, YK, Ling, SC, Murray, KF, Rodriguez-Baez, N, Schwarzenberg, SJ, Teckman, J, Ganova-Raeva, L, Rosenthal, P & Hepatitis B Research Network 2015, 'Children with Chronic Hepatitis B in the United States and Canada', The Journal of pediatrics, vol. 167, no. 6, pp. 1287-1294.e2. https://doi.org/10.1016/j.jpeds.2015.08.021
Schwarz KB, Cloonan YK, Ling SC, Murray KF, Rodriguez-Baez N, Schwarzenberg SJ et al. Children with Chronic Hepatitis B in the United States and Canada. The Journal of pediatrics. 2015 Dec 1;167(6):1287-1294.e2. https://doi.org/10.1016/j.jpeds.2015.08.021
Schwarz, Kathleen B. ; Cloonan, Yona Keich ; Ling, Simon C. ; Murray, Karen F. ; Rodriguez-Baez, Norberto ; Schwarzenberg, Sarah Jane ; Teckman, Jeffrey ; Ganova-Raeva, Lilia ; Rosenthal, Philip ; Hepatitis B Research Network. / Children with Chronic Hepatitis B in the United States and Canada. In: The Journal of pediatrics. 2015 ; Vol. 167, No. 6. pp. 1287-1294.e2.
@article{f1a7b9cd115740bdaeda0792204cb72e,
title = "Children with Chronic Hepatitis B in the United States and Canada",
abstract = "OBJECTIVES: To test the hypothesis that children with chronic hepatitis B living in the US and Canada would have international origins and characteristic hepatitis B virus (HBV) genotypes and laboratory profiles.STUDY DESIGN: Clinical characteristics of children enrolled in the Hepatitis B Research Network were collected from 7 US and Canadian centers.RESULTS: Children (n = 343) with an age range of 1.0-17.8 years were enrolled; 78{\%} of the children were Asian, 55{\%} were adopted, and 97{\%} had international origins with either the child or a parent born in 1 of 31 countries. The majority had HBV genotype B (43{\%}) or C (32{\%}), and the remainder had genotype A (5{\%}), D (16{\%}), E (4{\%}), or multiple (<1{\%}). Children with genotype B or C were more likely to be Asian (98{\%} and 96{\%}), more consistently hepatitis B envelope antigen positive (95{\%} and 82{\%}), had higher median HBV DNA levels (8.2 and 8.3 log10 IU/mL), and less frequently had elevated alanine aminotransferase values (43{\%} and 57{\%}) compared with children with other genotypes. The percentage of hepatitis B envelope antigen positivity and of those with HBV DNA ≥6 log₁₀ IU/mL declined with age.CONCLUSIONS: The majority of children in the Hepatitis B Research Network have HBV genotypes that reflect their international origins. Clinical and laboratory data differ substantially by patient age and HBV genotype. Use of these data can help drive the development of optimal strategies to manage and treat children with chronic hepatitis B.",
author = "Schwarz, {Kathleen B.} and Cloonan, {Yona Keich} and Ling, {Simon C.} and Murray, {Karen F.} and Norberto Rodriguez-Baez and Schwarzenberg, {Sarah Jane} and Jeffrey Teckman and Lilia Ganova-Raeva and Philip Rosenthal and {Hepatitis B Research Network}",
year = "2015",
month = "12",
day = "1",
doi = "10.1016/j.jpeds.2015.08.021",
language = "English (US)",
volume = "167",
pages = "1287--1294.e2",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - Children with Chronic Hepatitis B in the United States and Canada

AU - Schwarz, Kathleen B.

AU - Cloonan, Yona Keich

AU - Ling, Simon C.

AU - Murray, Karen F.

AU - Rodriguez-Baez, Norberto

AU - Schwarzenberg, Sarah Jane

AU - Teckman, Jeffrey

AU - Ganova-Raeva, Lilia

AU - Rosenthal, Philip

AU - Hepatitis B Research Network

PY - 2015/12/1

Y1 - 2015/12/1

N2 - OBJECTIVES: To test the hypothesis that children with chronic hepatitis B living in the US and Canada would have international origins and characteristic hepatitis B virus (HBV) genotypes and laboratory profiles.STUDY DESIGN: Clinical characteristics of children enrolled in the Hepatitis B Research Network were collected from 7 US and Canadian centers.RESULTS: Children (n = 343) with an age range of 1.0-17.8 years were enrolled; 78% of the children were Asian, 55% were adopted, and 97% had international origins with either the child or a parent born in 1 of 31 countries. The majority had HBV genotype B (43%) or C (32%), and the remainder had genotype A (5%), D (16%), E (4%), or multiple (<1%). Children with genotype B or C were more likely to be Asian (98% and 96%), more consistently hepatitis B envelope antigen positive (95% and 82%), had higher median HBV DNA levels (8.2 and 8.3 log10 IU/mL), and less frequently had elevated alanine aminotransferase values (43% and 57%) compared with children with other genotypes. The percentage of hepatitis B envelope antigen positivity and of those with HBV DNA ≥6 log₁₀ IU/mL declined with age.CONCLUSIONS: The majority of children in the Hepatitis B Research Network have HBV genotypes that reflect their international origins. Clinical and laboratory data differ substantially by patient age and HBV genotype. Use of these data can help drive the development of optimal strategies to manage and treat children with chronic hepatitis B.

AB - OBJECTIVES: To test the hypothesis that children with chronic hepatitis B living in the US and Canada would have international origins and characteristic hepatitis B virus (HBV) genotypes and laboratory profiles.STUDY DESIGN: Clinical characteristics of children enrolled in the Hepatitis B Research Network were collected from 7 US and Canadian centers.RESULTS: Children (n = 343) with an age range of 1.0-17.8 years were enrolled; 78% of the children were Asian, 55% were adopted, and 97% had international origins with either the child or a parent born in 1 of 31 countries. The majority had HBV genotype B (43%) or C (32%), and the remainder had genotype A (5%), D (16%), E (4%), or multiple (<1%). Children with genotype B or C were more likely to be Asian (98% and 96%), more consistently hepatitis B envelope antigen positive (95% and 82%), had higher median HBV DNA levels (8.2 and 8.3 log10 IU/mL), and less frequently had elevated alanine aminotransferase values (43% and 57%) compared with children with other genotypes. The percentage of hepatitis B envelope antigen positivity and of those with HBV DNA ≥6 log₁₀ IU/mL declined with age.CONCLUSIONS: The majority of children in the Hepatitis B Research Network have HBV genotypes that reflect their international origins. Clinical and laboratory data differ substantially by patient age and HBV genotype. Use of these data can help drive the development of optimal strategies to manage and treat children with chronic hepatitis B.

UR - http://www.scopus.com/inward/record.url?scp=85027926289&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027926289&partnerID=8YFLogxK

U2 - 10.1016/j.jpeds.2015.08.021

DO - 10.1016/j.jpeds.2015.08.021

M3 - Article

VL - 167

SP - 1287-1294.e2

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 6

ER -