Childhood trauma and clinical high risk for psychosis

Rachel L. Loewy, Sarah Corey, Felix Amirfathi, Sawsan Dabit, Daniel Fulford, Rahel Pearson, Jessica P.Y. Hua, Danielle Schlosser, Barbara K. Stuart, Daniel H. Mathalon, Sophia Vinogradov

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

As a risk factor for psychosis, childhood trauma rates are elevated in the clinical-high-risk (CHR) syndrome compared to the general population. However, it is unknown whether trauma is typically experienced in childhood or adolescence/young adulthood, whether it occurred prior to CHR syndrome onset, and how severe trauma relates to presenting symptoms. In this study, we examined the relationship of trauma history to symptoms and functioning in individuals diagnosed with the CHR syndrome on the Structured Interview for Psychosis-Risk Syndromes (N = 103). Trauma, defined as meeting the DSM-IV A1 criterion of actual or threatened death or injury, was assessed by semi-structured interview. A large proportion of CHR participants (61%) reported trauma exposure, including interpersonal trauma, trauma prior to CHR onset, and childhood trauma prior to age 12. Those with a trauma history (versus those without trauma) were rated as having more severe perceptual disturbances, general/affective symptoms and more impairment on the Global Assessment of Functioning Scale. The number of traumatic events correlated with more severe ratings in those three domains. Additionally, the number of interpersonal traumas was correlated with ratings of suspiciousness. Trauma was unrelated to specific measures of social and role functioning. A small proportion of CHR participants were diagnosed with formal PTSD (14%), which was unrelated to symptom severity or functioning. Thus, we demonstrate that trauma exposure is often early in life (before age 12), occurs prior to the onset of the CHR syndrome, and is related to both positive and affective symptoms.

Original languageEnglish (US)
Pages (from-to)10-14
Number of pages5
JournalSchizophrenia Research
Volume205
DOIs
StatePublished - Mar 1 2019

Fingerprint

Psychotic Disorders
Wounds and Injuries
Affective Symptoms
Interviews
Post-Traumatic Stress Disorders
Diagnostic and Statistical Manual of Mental Disorders

Keywords

  • Adverse childhood events
  • Prodrome
  • Schizophrenia
  • Stress
  • Ultra high risk

PubMed: MeSH publication types

  • Journal Article

Cite this

Loewy, R. L., Corey, S., Amirfathi, F., Dabit, S., Fulford, D., Pearson, R., ... Vinogradov, S. (2019). Childhood trauma and clinical high risk for psychosis. Schizophrenia Research, 205, 10-14. https://doi.org/10.1016/j.schres.2018.05.003

Childhood trauma and clinical high risk for psychosis. / Loewy, Rachel L.; Corey, Sarah; Amirfathi, Felix; Dabit, Sawsan; Fulford, Daniel; Pearson, Rahel; Hua, Jessica P.Y.; Schlosser, Danielle; Stuart, Barbara K.; Mathalon, Daniel H.; Vinogradov, Sophia.

In: Schizophrenia Research, Vol. 205, 01.03.2019, p. 10-14.

Research output: Contribution to journalArticle

Loewy, RL, Corey, S, Amirfathi, F, Dabit, S, Fulford, D, Pearson, R, Hua, JPY, Schlosser, D, Stuart, BK, Mathalon, DH & Vinogradov, S 2019, 'Childhood trauma and clinical high risk for psychosis', Schizophrenia Research, vol. 205, pp. 10-14. https://doi.org/10.1016/j.schres.2018.05.003
Loewy RL, Corey S, Amirfathi F, Dabit S, Fulford D, Pearson R et al. Childhood trauma and clinical high risk for psychosis. Schizophrenia Research. 2019 Mar 1;205:10-14. https://doi.org/10.1016/j.schres.2018.05.003
Loewy, Rachel L. ; Corey, Sarah ; Amirfathi, Felix ; Dabit, Sawsan ; Fulford, Daniel ; Pearson, Rahel ; Hua, Jessica P.Y. ; Schlosser, Danielle ; Stuart, Barbara K. ; Mathalon, Daniel H. ; Vinogradov, Sophia. / Childhood trauma and clinical high risk for psychosis. In: Schizophrenia Research. 2019 ; Vol. 205. pp. 10-14.
@article{56c160f04c464bf1816278f6d5155e83,
title = "Childhood trauma and clinical high risk for psychosis",
abstract = "As a risk factor for psychosis, childhood trauma rates are elevated in the clinical-high-risk (CHR) syndrome compared to the general population. However, it is unknown whether trauma is typically experienced in childhood or adolescence/young adulthood, whether it occurred prior to CHR syndrome onset, and how severe trauma relates to presenting symptoms. In this study, we examined the relationship of trauma history to symptoms and functioning in individuals diagnosed with the CHR syndrome on the Structured Interview for Psychosis-Risk Syndromes (N = 103). Trauma, defined as meeting the DSM-IV A1 criterion of actual or threatened death or injury, was assessed by semi-structured interview. A large proportion of CHR participants (61{\%}) reported trauma exposure, including interpersonal trauma, trauma prior to CHR onset, and childhood trauma prior to age 12. Those with a trauma history (versus those without trauma) were rated as having more severe perceptual disturbances, general/affective symptoms and more impairment on the Global Assessment of Functioning Scale. The number of traumatic events correlated with more severe ratings in those three domains. Additionally, the number of interpersonal traumas was correlated with ratings of suspiciousness. Trauma was unrelated to specific measures of social and role functioning. A small proportion of CHR participants were diagnosed with formal PTSD (14{\%}), which was unrelated to symptom severity or functioning. Thus, we demonstrate that trauma exposure is often early in life (before age 12), occurs prior to the onset of the CHR syndrome, and is related to both positive and affective symptoms.",
keywords = "Adverse childhood events, Prodrome, Schizophrenia, Stress, Ultra high risk",
author = "Loewy, {Rachel L.} and Sarah Corey and Felix Amirfathi and Sawsan Dabit and Daniel Fulford and Rahel Pearson and Hua, {Jessica P.Y.} and Danielle Schlosser and Stuart, {Barbara K.} and Mathalon, {Daniel H.} and Sophia Vinogradov",
year = "2019",
month = "3",
day = "1",
doi = "10.1016/j.schres.2018.05.003",
language = "English (US)",
volume = "205",
pages = "10--14",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",

}

TY - JOUR

T1 - Childhood trauma and clinical high risk for psychosis

AU - Loewy, Rachel L.

AU - Corey, Sarah

AU - Amirfathi, Felix

AU - Dabit, Sawsan

AU - Fulford, Daniel

AU - Pearson, Rahel

AU - Hua, Jessica P.Y.

AU - Schlosser, Danielle

AU - Stuart, Barbara K.

AU - Mathalon, Daniel H.

AU - Vinogradov, Sophia

PY - 2019/3/1

Y1 - 2019/3/1

N2 - As a risk factor for psychosis, childhood trauma rates are elevated in the clinical-high-risk (CHR) syndrome compared to the general population. However, it is unknown whether trauma is typically experienced in childhood or adolescence/young adulthood, whether it occurred prior to CHR syndrome onset, and how severe trauma relates to presenting symptoms. In this study, we examined the relationship of trauma history to symptoms and functioning in individuals diagnosed with the CHR syndrome on the Structured Interview for Psychosis-Risk Syndromes (N = 103). Trauma, defined as meeting the DSM-IV A1 criterion of actual or threatened death or injury, was assessed by semi-structured interview. A large proportion of CHR participants (61%) reported trauma exposure, including interpersonal trauma, trauma prior to CHR onset, and childhood trauma prior to age 12. Those with a trauma history (versus those without trauma) were rated as having more severe perceptual disturbances, general/affective symptoms and more impairment on the Global Assessment of Functioning Scale. The number of traumatic events correlated with more severe ratings in those three domains. Additionally, the number of interpersonal traumas was correlated with ratings of suspiciousness. Trauma was unrelated to specific measures of social and role functioning. A small proportion of CHR participants were diagnosed with formal PTSD (14%), which was unrelated to symptom severity or functioning. Thus, we demonstrate that trauma exposure is often early in life (before age 12), occurs prior to the onset of the CHR syndrome, and is related to both positive and affective symptoms.

AB - As a risk factor for psychosis, childhood trauma rates are elevated in the clinical-high-risk (CHR) syndrome compared to the general population. However, it is unknown whether trauma is typically experienced in childhood or adolescence/young adulthood, whether it occurred prior to CHR syndrome onset, and how severe trauma relates to presenting symptoms. In this study, we examined the relationship of trauma history to symptoms and functioning in individuals diagnosed with the CHR syndrome on the Structured Interview for Psychosis-Risk Syndromes (N = 103). Trauma, defined as meeting the DSM-IV A1 criterion of actual or threatened death or injury, was assessed by semi-structured interview. A large proportion of CHR participants (61%) reported trauma exposure, including interpersonal trauma, trauma prior to CHR onset, and childhood trauma prior to age 12. Those with a trauma history (versus those without trauma) were rated as having more severe perceptual disturbances, general/affective symptoms and more impairment on the Global Assessment of Functioning Scale. The number of traumatic events correlated with more severe ratings in those three domains. Additionally, the number of interpersonal traumas was correlated with ratings of suspiciousness. Trauma was unrelated to specific measures of social and role functioning. A small proportion of CHR participants were diagnosed with formal PTSD (14%), which was unrelated to symptom severity or functioning. Thus, we demonstrate that trauma exposure is often early in life (before age 12), occurs prior to the onset of the CHR syndrome, and is related to both positive and affective symptoms.

KW - Adverse childhood events

KW - Prodrome

KW - Schizophrenia

KW - Stress

KW - Ultra high risk

UR - http://www.scopus.com/inward/record.url?scp=85047176568&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047176568&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2018.05.003

DO - 10.1016/j.schres.2018.05.003

M3 - Article

C2 - 29779964

AN - SCOPUS:85047176568

VL - 205

SP - 10

EP - 14

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

ER -