Childhood cancer risk in those with chromosomal and non-chromosomal congenital anomalies in Washington State: 1984-2013

Marlena S. Norwood, Philip J. Lupo, Eric J. Chow, Michael E. Scheurer, Sharon E. Plon, Heather E. Danysh, Logan G. Spector, Susan E. Carozza, David R. Doody, Beth A. Mueller

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Abstract

Background: The presence of a congenital anomaly is associated with increased childhood cancer risk, likely due to large effects of Down syndrome and chromosomal anomalies for leukemia. Less is known about associations with presence of non-chromosomal anomalies. Methods: Records of children diagnosed with cancer at <20 years of age during 1984-2013 in Washington State cancer registries were linked to their birth certificates (N = 4,105). A comparison group of children born in the same years was identified. Congenital anomalies were assessed from birth records and diagnosis codes in linked hospital discharge data. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for cancer, and for specific cancer types in relation to the presence of any anomaly and specific anomalies. Results: Having any congenital anomaly was associated with an increased risk of childhood cancer (OR: 1.46, 95% CI 1.28-1.65). Non-chromosomal anomalies were also associated with increased childhood cancer risk overall (OR: 1.35; 95% CI: 1.18-1.54), and with increased risk of several cancer types, including neuroblastoma, renal, hepatoblastoma, soft-tissue sarcoma, and germ cell tumors. Increasing number of non-chromosomal anomalies was associated with a stronger risk of childhood cancer (OR for 3+ anomalies: 3.11, 95% CI: 1.54-6.11). Although central nervous system (CNS) anomalies were associated with CNS tumors (OR: 6.05, 95% CI 2.75-13.27), there was no strong evidence of other non-chromosomal anomalies being specifically associated with cancer occurring in the same organ system or anatomic location. Conclusions: Non-chromosomal anomalies increased risk of several cancer types. Additionally, we found that increasing number of non-chromosomal anomalies was associated with a stronger risk of cancer. Pooling similar data from many regions would increase power to identify specific associations in order to inform molecular studies examining possible common developmental pathways in the etiologies of birth defects and cancer.

Original languageEnglish (US)
Article numbere0179006
JournalPloS one
Volume12
Issue number6
DOIs
StatePublished - Jun 2017

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childhood
neoplasms
Neoplasms
odds ratio
Neurology
Odds Ratio
confidence interval
Confidence Intervals
Tumors
Birth Certificates
Logistics
central nervous system
Cells
Nervous System Malformations
Hepatoblastoma
Tissue
Central Nervous System Neoplasms
Down syndrome
Defects
Germ Cell and Embryonal Neoplasms

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Norwood, M. S., Lupo, P. J., Chow, E. J., Scheurer, M. E., Plon, S. E., Danysh, H. E., ... Mueller, B. A. (2017). Childhood cancer risk in those with chromosomal and non-chromosomal congenital anomalies in Washington State: 1984-2013. PloS one, 12(6), [e0179006]. https://doi.org/10.1371/journal.pone.0179006

Childhood cancer risk in those with chromosomal and non-chromosomal congenital anomalies in Washington State : 1984-2013. / Norwood, Marlena S.; Lupo, Philip J.; Chow, Eric J.; Scheurer, Michael E.; Plon, Sharon E.; Danysh, Heather E.; Spector, Logan G.; Carozza, Susan E.; Doody, David R.; Mueller, Beth A.

In: PloS one, Vol. 12, No. 6, e0179006, 06.2017.

Research output: Contribution to journalArticle

Norwood, MS, Lupo, PJ, Chow, EJ, Scheurer, ME, Plon, SE, Danysh, HE, Spector, LG, Carozza, SE, Doody, DR & Mueller, BA 2017, 'Childhood cancer risk in those with chromosomal and non-chromosomal congenital anomalies in Washington State: 1984-2013', PloS one, vol. 12, no. 6, e0179006. https://doi.org/10.1371/journal.pone.0179006
Norwood, Marlena S. ; Lupo, Philip J. ; Chow, Eric J. ; Scheurer, Michael E. ; Plon, Sharon E. ; Danysh, Heather E. ; Spector, Logan G. ; Carozza, Susan E. ; Doody, David R. ; Mueller, Beth A. / Childhood cancer risk in those with chromosomal and non-chromosomal congenital anomalies in Washington State : 1984-2013. In: PloS one. 2017 ; Vol. 12, No. 6.
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title = "Childhood cancer risk in those with chromosomal and non-chromosomal congenital anomalies in Washington State: 1984-2013",
abstract = "Background: The presence of a congenital anomaly is associated with increased childhood cancer risk, likely due to large effects of Down syndrome and chromosomal anomalies for leukemia. Less is known about associations with presence of non-chromosomal anomalies. Methods: Records of children diagnosed with cancer at <20 years of age during 1984-2013 in Washington State cancer registries were linked to their birth certificates (N = 4,105). A comparison group of children born in the same years was identified. Congenital anomalies were assessed from birth records and diagnosis codes in linked hospital discharge data. Logistic regression was used to estimate odds ratios (OR) and 95{\%} confidence intervals (CI) for cancer, and for specific cancer types in relation to the presence of any anomaly and specific anomalies. Results: Having any congenital anomaly was associated with an increased risk of childhood cancer (OR: 1.46, 95{\%} CI 1.28-1.65). Non-chromosomal anomalies were also associated with increased childhood cancer risk overall (OR: 1.35; 95{\%} CI: 1.18-1.54), and with increased risk of several cancer types, including neuroblastoma, renal, hepatoblastoma, soft-tissue sarcoma, and germ cell tumors. Increasing number of non-chromosomal anomalies was associated with a stronger risk of childhood cancer (OR for 3+ anomalies: 3.11, 95{\%} CI: 1.54-6.11). Although central nervous system (CNS) anomalies were associated with CNS tumors (OR: 6.05, 95{\%} CI 2.75-13.27), there was no strong evidence of other non-chromosomal anomalies being specifically associated with cancer occurring in the same organ system or anatomic location. Conclusions: Non-chromosomal anomalies increased risk of several cancer types. Additionally, we found that increasing number of non-chromosomal anomalies was associated with a stronger risk of cancer. Pooling similar data from many regions would increase power to identify specific associations in order to inform molecular studies examining possible common developmental pathways in the etiologies of birth defects and cancer.",
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AU - Norwood, Marlena S.

AU - Lupo, Philip J.

AU - Chow, Eric J.

AU - Scheurer, Michael E.

AU - Plon, Sharon E.

AU - Danysh, Heather E.

AU - Spector, Logan G.

AU - Carozza, Susan E.

AU - Doody, David R.

AU - Mueller, Beth A.

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N2 - Background: The presence of a congenital anomaly is associated with increased childhood cancer risk, likely due to large effects of Down syndrome and chromosomal anomalies for leukemia. Less is known about associations with presence of non-chromosomal anomalies. Methods: Records of children diagnosed with cancer at <20 years of age during 1984-2013 in Washington State cancer registries were linked to their birth certificates (N = 4,105). A comparison group of children born in the same years was identified. Congenital anomalies were assessed from birth records and diagnosis codes in linked hospital discharge data. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for cancer, and for specific cancer types in relation to the presence of any anomaly and specific anomalies. Results: Having any congenital anomaly was associated with an increased risk of childhood cancer (OR: 1.46, 95% CI 1.28-1.65). Non-chromosomal anomalies were also associated with increased childhood cancer risk overall (OR: 1.35; 95% CI: 1.18-1.54), and with increased risk of several cancer types, including neuroblastoma, renal, hepatoblastoma, soft-tissue sarcoma, and germ cell tumors. Increasing number of non-chromosomal anomalies was associated with a stronger risk of childhood cancer (OR for 3+ anomalies: 3.11, 95% CI: 1.54-6.11). Although central nervous system (CNS) anomalies were associated with CNS tumors (OR: 6.05, 95% CI 2.75-13.27), there was no strong evidence of other non-chromosomal anomalies being specifically associated with cancer occurring in the same organ system or anatomic location. Conclusions: Non-chromosomal anomalies increased risk of several cancer types. Additionally, we found that increasing number of non-chromosomal anomalies was associated with a stronger risk of cancer. Pooling similar data from many regions would increase power to identify specific associations in order to inform molecular studies examining possible common developmental pathways in the etiologies of birth defects and cancer.

AB - Background: The presence of a congenital anomaly is associated with increased childhood cancer risk, likely due to large effects of Down syndrome and chromosomal anomalies for leukemia. Less is known about associations with presence of non-chromosomal anomalies. Methods: Records of children diagnosed with cancer at <20 years of age during 1984-2013 in Washington State cancer registries were linked to their birth certificates (N = 4,105). A comparison group of children born in the same years was identified. Congenital anomalies were assessed from birth records and diagnosis codes in linked hospital discharge data. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for cancer, and for specific cancer types in relation to the presence of any anomaly and specific anomalies. Results: Having any congenital anomaly was associated with an increased risk of childhood cancer (OR: 1.46, 95% CI 1.28-1.65). Non-chromosomal anomalies were also associated with increased childhood cancer risk overall (OR: 1.35; 95% CI: 1.18-1.54), and with increased risk of several cancer types, including neuroblastoma, renal, hepatoblastoma, soft-tissue sarcoma, and germ cell tumors. Increasing number of non-chromosomal anomalies was associated with a stronger risk of childhood cancer (OR for 3+ anomalies: 3.11, 95% CI: 1.54-6.11). Although central nervous system (CNS) anomalies were associated with CNS tumors (OR: 6.05, 95% CI 2.75-13.27), there was no strong evidence of other non-chromosomal anomalies being specifically associated with cancer occurring in the same organ system or anatomic location. Conclusions: Non-chromosomal anomalies increased risk of several cancer types. Additionally, we found that increasing number of non-chromosomal anomalies was associated with a stronger risk of cancer. Pooling similar data from many regions would increase power to identify specific associations in order to inform molecular studies examining possible common developmental pathways in the etiologies of birth defects and cancer.

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