Childhood cancer incidence in relation to sunlight exposure

J. R B Musselman, L. G. Spector

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background:There is increasing interest in the possible association between cancer incidence and vitamin D through its role as a regulator of cell growth and differentiation. Epidemiological studies in adults and one paediatric study suggest an inverse association between sunlight exposure and cancer incidence.Methods:We carried out an ecological study using childhood cancer registry data and two population-level surrogates of sunlight exposure, (1) latitude of the registry city or population centroid of the registry nation and (2) annual solar radiation. All models were adjusted for nation-level socioeconomic status using socioeconomic indicators.Results:Latitude and radiation were significantly associated with cancer incidence, and the direction of association was consistent between the surrogates. Findings were not consistent across tumour types.Conclusion:Our ecological study offers some evidence to support an association between sunlight exposure and risk of childhood cancer.

Original languageEnglish (US)
Pages (from-to)214-220
Number of pages7
JournalBritish Journal of Cancer
Volume104
Issue number1
DOIs
StatePublished - Jan 4 2011

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health Pediatric Cancer Epidemiology Training Grant T32 CA099936 and the Children’s Cancer Research Fund, Minneapolis, MN, USA

Keywords

  • childhood cancer
  • sunlight
  • vitamin D

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