Child maltreatment, adaptive functioning, and polygenic risk: A structural equation mixture model

Eric L Thibodeau, Katherine E. Masyn, Fred A. Rogosch, Dante Cicchetti

Research output: Contribution to journalArticle

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Abstract

This study used a structural equation mixture model to examine associations between child maltreatment, polygenic risk, and indices of adaptive functioning. Children aged 6 to 13 years (N = 1,004), half maltreated, half nonmaltreated, were recruited to attend a research day camp. Multi-informant indicators of prosocial behavior, antisocial behavior, withdrawn behavior, and depression were collected and used in a latent class analysis. Four classes emerged, characterizing well-adjusted, externalizing, internalizing, and socially dominant groups. Twelve genetic variants, previously reported in the Gene × Environment literature, were modeled as one weighted polygenic risk score. Large main effects between maltreatment and adaptive functioning were observed (Wald = 35.3, df = 3, p <.0001), along with evidence of a small Gene × Environment effect (Wald = 13.5, df = 3, p =.004), adjusting for sex, age, and covariate interaction effects.

Original languageEnglish (US)
Pages (from-to)443-456
Number of pages14
JournalDevelopment and psychopathology
Volume31
Issue number2
DOIs
StatePublished - May 1 2019

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PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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