Chemotactic and phagocytic responses of human alveolar macrophages to activated complement components

S. W. Richards; P. K. Peterson; H. A. Verbrugh; R. D. Nelson; D. E. Hammerschmidt; J. R. Hoidal

doi:10.1128/iai.43.2.775-778.1984

Chemotactic and phagocytic responses of human alveolar macrophages to activated complement components

S. W. Richards, P. K. Peterson, H. A. Verbrugh, R. D. Nelson, D. E. Hammerschmidt, J. R. Hoidal

Medicine - Hematology, Oncology, Transplant

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Human alveolar macrophages (AMs) migrated toward and aggregated to C5a but not toward C5a-deficient serum. Human AMs from cigarette smokers migrated significantly farther than did AMs from nonsmokers. Human AMs phagocytized Escherichia coli opsonized with activated C3. Immunoglobulin G was not required for phagocytosis. Human AMs demonstrate chemotaxis and aggregation to C5a. Further, human AMs can phagocytize bacteria coated with activated C3.

Original language	English (US)
Pages (from-to)	775-778
Number of pages	4
Journal	Infection and immunity
Volume	43
Issue number	2
DOIs	https://doi.org/10.1128/iai.43.2.775-778.1984
State	Published - 1984

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title = "Chemotactic and phagocytic responses of human alveolar macrophages to activated complement components",

abstract = "Human alveolar macrophages (AMs) migrated toward and aggregated to C5a but not toward C5a-deficient serum. Human AMs from cigarette smokers migrated significantly farther than did AMs from nonsmokers. Human AMs phagocytized Escherichia coli opsonized with activated C3. Immunoglobulin G was not required for phagocytosis. Human AMs demonstrate chemotaxis and aggregation to C5a. Further, human AMs can phagocytize bacteria coated with activated C3.",

author = "Richards, {S. W.} and Peterson, {P. K.} and Verbrugh, {H. A.} and Nelson, {R. D.} and Hammerschmidt, {D. E.} and Hoidal, {J. R.}",

year = "1984",

doi = "10.1128/iai.43.2.775-778.1984",

language = "English (US)",

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T1 - Chemotactic and phagocytic responses of human alveolar macrophages to activated complement components

AU - Richards, S. W.

AU - Peterson, P. K.

AU - Verbrugh, H. A.

AU - Nelson, R. D.

AU - Hammerschmidt, D. E.

AU - Hoidal, J. R.

PY - 1984

Y1 - 1984

N2 - Human alveolar macrophages (AMs) migrated toward and aggregated to C5a but not toward C5a-deficient serum. Human AMs from cigarette smokers migrated significantly farther than did AMs from nonsmokers. Human AMs phagocytized Escherichia coli opsonized with activated C3. Immunoglobulin G was not required for phagocytosis. Human AMs demonstrate chemotaxis and aggregation to C5a. Further, human AMs can phagocytize bacteria coated with activated C3.

AB - Human alveolar macrophages (AMs) migrated toward and aggregated to C5a but not toward C5a-deficient serum. Human AMs from cigarette smokers migrated significantly farther than did AMs from nonsmokers. Human AMs phagocytized Escherichia coli opsonized with activated C3. Immunoglobulin G was not required for phagocytosis. Human AMs demonstrate chemotaxis and aggregation to C5a. Further, human AMs can phagocytize bacteria coated with activated C3.

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AN - SCOPUS:0021347041

VL - 43

SP - 775

EP - 778

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 2

ER -

Chemotactic and phagocytic responses of human alveolar macrophages to activated complement components

Abstract

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