Chemotactic and phagocytic responses of human alveolar macrophages to activated complement components

S. W. Richards, P. K. Peterson, H. A. Verbrugh, R. D. Nelson, D. E. Hammerschmidt, J. R. Hoidal

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Human alveolar macrophages (AMs) migrated toward and aggregated to C5a but not toward C5a-deficient serum. Human AMs from cigarette smokers migrated significantly farther than did AMs from nonsmokers. Human AMs phagocytized Escherichia coli opsonized with activated C3. Immunoglobulin G was not required for phagocytosis. Human AMs demonstrate chemotaxis and aggregation to C5a. Further, human AMs can phagocytize bacteria coated with activated C3.

Original languageEnglish (US)
Pages (from-to)775-778
Number of pages4
JournalInfection and immunity
Volume43
Issue number2
DOIs
StatePublished - 1984

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