Chemoselective enrichment for natural products discovery

Antoinette Y. Odendaal, Darci J. Trader, Erin E. Carlson

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Natural products account for a significant proportion of modern day therapeutic agents. However, the discovery of novel compounds is hindered by the isolation process, which often relies upon extraction and chromatographic separation techniques. These methods, which are dependent upon the physicochemical properties of the compounds, have a limited ability to both purify and concentrate the minor components of a biological extract.We have devised an isolation strategy based upon an orthogonal chemical feature, namely, functional group composition. Development of a functional group-targeted method is expected to achieve exceptional resolution given the large number of distinct moieties present in natural product extracts. Here, we describe the generation of controllably reversible covalent enrichment tags for the chemoselective isolation of alcohol-containing natural products from complex mixtures.

Original languageEnglish (US)
Pages (from-to)760-764
Number of pages5
JournalChemical Science
Volume2
Issue number4
DOIs
StatePublished - 2011

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