Chemopreventive effect of aerosolized polyphenon E on lung tumorigenesis in A/J mice

Ying Yan; Julie Cook; Jay McQuillan; Guifang Zhang; Cory J. Hitzman; Yian Wang; Timothy S. Wiedmann; Ming You

doi:10.1593/neo.07160

Chemopreventive effect of aerosolized polyphenon E on lung tumorigenesis in A/J mice

Ying Yan
, Julie Cook
, Jay McQuillan
, Guifang Zhang
, Cory J. Hitzman
, Yian Wang
, Timothy S. Wiedmann
, Ming You

Pharmaceutics

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Effective chemoprevention of lung cancer in high-risk patients through the administration of pharmacologic or nutritional agents is urgently needed. Aerosol inhalation can deliver chemopreventive agents directly to the respiratory tract to inhibit the tumorigenic process. In this study, polyphenon E (PolyE) and (-)-epigallocatechin-3-gallate (EGCG) were administered by aerosol delivery to A/J mice beginning 2 weeks after carcinogen treatment and continuing daily by inhalation throughout the remainder of the study (20 weeks). PolyE decreased tumor load by ∼ 59%. However, EGCG, both at the same dose and at a higher dose, failed to inhibit lung carcinogenesis. These results indicate that aerosol delivery of PolyE, but not EGCG, may be a useful chemopreventive protocol in subjects at high risk for lung cancer.

Original language	English (US)
Pages (from-to)	401-405
Number of pages	5
Journal	Neoplasia
Volume	9
Issue number	5
DOIs	https://doi.org/10.1593/neo.07160
State	Published - May 2007

Bibliographical note

Funding Information:
Address all correspondence to: Ming You, Department of Surgery, The Alvin J. Siteman Cancer Center, Washington University in St. Louis, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO 63110. E-mail: [email protected] 1This work was supported, in part, by grants (R01 CA113793 and P01 CA9696401) from the National Cancer Institute, National Institutes of Health. 2Present address: Boston Scientific, Inc., Maple Grove, MN, USA. Received 2 February 2007; Revised 8 March 2007; Accepted 12 March 2007.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aerosol
Chemoprevention
Lung tumorigenesis
Mouse
Polyphenon E

Publisher link

10.1593/neo.07160

Find It

Find It at U of M Libraries

Cite this

@article{81f35ddabda045b597984b25dacb4546,

title = "Chemopreventive effect of aerosolized polyphenon E on lung tumorigenesis in A/J mice",

abstract = "Effective chemoprevention of lung cancer in high-risk patients through the administration of pharmacologic or nutritional agents is urgently needed. Aerosol inhalation can deliver chemopreventive agents directly to the respiratory tract to inhibit the tumorigenic process. In this study, polyphenon E (PolyE) and (-)-epigallocatechin-3-gallate (EGCG) were administered by aerosol delivery to A/J mice beginning 2 weeks after carcinogen treatment and continuing daily by inhalation throughout the remainder of the study (20 weeks). PolyE decreased tumor load by ∼ 59\%. However, EGCG, both at the same dose and at a higher dose, failed to inhibit lung carcinogenesis. These results indicate that aerosol delivery of PolyE, but not EGCG, may be a useful chemopreventive protocol in subjects at high risk for lung cancer.",

keywords = "Aerosol, Chemoprevention, Lung tumorigenesis, Mouse, Polyphenon E",

author = "Ying Yan and Julie Cook and Jay McQuillan and Guifang Zhang and Hitzman, \{Cory J.\} and Yian Wang and Wiedmann, \{Timothy S.\} and Ming You",

note = "Funding Information: Address all correspondence to: Ming You, Department of Surgery, The Alvin J. Siteman Cancer Center, Washington University in St. Louis, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO 63110. E-mail: [email protected] 1This work was supported, in part, by grants (R01 CA113793 and P01 CA9696401) from the National Cancer Institute, National Institutes of Health. 2Present address: Boston Scientific, Inc., Maple Grove, MN, USA. Received 2 February 2007; Revised 8 March 2007; Accepted 12 March 2007.",

year = "2007",

month = may,

doi = "10.1593/neo.07160",

language = "English (US)",

volume = "9",

pages = "401--405",

journal = "Neoplasia",

issn = "1522-8002",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Chemopreventive effect of aerosolized polyphenon E on lung tumorigenesis in A/J mice

AU - Yan, Ying

AU - Cook, Julie

AU - McQuillan, Jay

AU - Zhang, Guifang

AU - Hitzman, Cory J.

AU - Wang, Yian

AU - Wiedmann, Timothy S.

AU - You, Ming

N1 - Funding Information: Address all correspondence to: Ming You, Department of Surgery, The Alvin J. Siteman Cancer Center, Washington University in St. Louis, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO 63110. E-mail: [email protected] 1This work was supported, in part, by grants (R01 CA113793 and P01 CA9696401) from the National Cancer Institute, National Institutes of Health. 2Present address: Boston Scientific, Inc., Maple Grove, MN, USA. Received 2 February 2007; Revised 8 March 2007; Accepted 12 March 2007.

PY - 2007/5

Y1 - 2007/5

N2 - Effective chemoprevention of lung cancer in high-risk patients through the administration of pharmacologic or nutritional agents is urgently needed. Aerosol inhalation can deliver chemopreventive agents directly to the respiratory tract to inhibit the tumorigenic process. In this study, polyphenon E (PolyE) and (-)-epigallocatechin-3-gallate (EGCG) were administered by aerosol delivery to A/J mice beginning 2 weeks after carcinogen treatment and continuing daily by inhalation throughout the remainder of the study (20 weeks). PolyE decreased tumor load by ∼ 59%. However, EGCG, both at the same dose and at a higher dose, failed to inhibit lung carcinogenesis. These results indicate that aerosol delivery of PolyE, but not EGCG, may be a useful chemopreventive protocol in subjects at high risk for lung cancer.

AB - Effective chemoprevention of lung cancer in high-risk patients through the administration of pharmacologic or nutritional agents is urgently needed. Aerosol inhalation can deliver chemopreventive agents directly to the respiratory tract to inhibit the tumorigenic process. In this study, polyphenon E (PolyE) and (-)-epigallocatechin-3-gallate (EGCG) were administered by aerosol delivery to A/J mice beginning 2 weeks after carcinogen treatment and continuing daily by inhalation throughout the remainder of the study (20 weeks). PolyE decreased tumor load by ∼ 59%. However, EGCG, both at the same dose and at a higher dose, failed to inhibit lung carcinogenesis. These results indicate that aerosol delivery of PolyE, but not EGCG, may be a useful chemopreventive protocol in subjects at high risk for lung cancer.

KW - Aerosol

KW - Chemoprevention

KW - Lung tumorigenesis

KW - Mouse

KW - Polyphenon E

UR - https://www.scopus.com/pages/publications/34249002243

UR - https://www.scopus.com/pages/publications/34249002243#tab=citedBy

U2 - 10.1593/neo.07160

DO - 10.1593/neo.07160

M3 - Article

C2 - 17534445

AN - SCOPUS:34249002243

SN - 1522-8002

VL - 9

SP - 401

EP - 405

JO - Neoplasia

JF - Neoplasia

IS - 5

ER -

Chemopreventive effect of aerosolized polyphenon E on lung tumorigenesis in A/J mice

Abstract

Bibliographical note

UN SDGs

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Cite this