Effective chemoprevention of lung cancer in high-risk patients through the administration of pharmacologic or nutritional agents is urgently needed. Aerosol inhalation can deliver chemopreventive agents directly to the respiratory tract to inhibit the tumorigenic process. In this study, polyphenon E (PolyE) and (-)-epigallocatechin-3-gallate (EGCG) were administered by aerosol delivery to A/J mice beginning 2 weeks after carcinogen treatment and continuing daily by inhalation throughout the remainder of the study (20 weeks). PolyE decreased tumor load by ∼ 59%. However, EGCG, both at the same dose and at a higher dose, failed to inhibit lung carcinogenesis. These results indicate that aerosol delivery of PolyE, but not EGCG, may be a useful chemopreventive protocol in subjects at high risk for lung cancer.
Bibliographical noteFunding Information:
Address all correspondence to: Ming You, Department of Surgery, The Alvin J. Siteman Cancer Center, Washington University in St. Louis, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO 63110. E-mail: firstname.lastname@example.org 1This work was supported, in part, by grants (R01 CA113793 and P01 CA9696401) from the National Cancer Institute, National Institutes of Health. 2Present address: Boston Scientific, Inc., Maple Grove, MN, USA. Received 2 February 2007; Revised 8 March 2007; Accepted 12 March 2007.
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- Lung tumorigenesis
- Polyphenon E