Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers

Research output: Contribution to journalReview article

74 Scopus citations

Abstract

Chemoprevention of lung carcinogenesis is one approach to controlling the epidemic of lung cancer caused by cigarette smoking. The target for chemoprevention should be the activities of the multiple carcinogens, toxicants, co-carcinogens, tumour promoters and inflammatory compounds in cigarette smoke. At present there are many agents, both synthetic and naturally occurring, that prevent lung tumour development in well-established animal models. It seems likely that logically constructed mixtures of these agents, developed from the ground up, will be necessary for the prevention of lung carcinogenesis.

Original languageEnglish (US)
Pages (from-to)476-488
Number of pages13
JournalNature Reviews Cancer
Volume9
Issue number7
DOIs
StatePublished - Jul 1 2009

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