Chemokines and Their Receptors in Intracerebral Hemorrhage

Yao Yao, Stella E. Tsirka

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Intracerebral hemorrhage (ICH) is a devastating clinical event which results in a high rate of disability and death. At present, no effective treatment is available for ICH. Accumulating evidence suggests that inflammatory responses contribute significantly to the ICH-induced secondary brain outcomes. During ICH, inflammatory cells accumulate at the ICH site attracted by gradients of chemokines. This review summarizes recent progress in ICH studies and the chemoattractants that act during the injury and focuses on and introduces the basic biology of the chemokine monocyte chemoattractant protein-1 (MCP1) and its role in the progression of ICH. Better understanding of MCP1 signaling cascade and the compensation after its inhibition could shed light on the development of effective treatments for ICH.

Original languageEnglish (US)
Pages (from-to)70-79
Number of pages10
JournalTranslational Stroke Research
Issue numberSUPPL. 1
StatePublished - Jul 2012
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgments We thank members of the Tsirka lab for helpful questions and contributions. This work was supported by a SigmaXi grant-in-aid (to YY) and NIH R0142168 (to SET). The authors declare no conflicts of interest.


  • Chemokines
  • MCP1
  • Mouse


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