Chemokine CXCL10 (IP-10) is sufficient to trigger an immune response to injected antigens in a mouse model

Mitchell D. Krathwohl, Jodi L. Anderson

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The induction of chemokines by interferons might represent a link between innate and adaptive immunity. Whether these induced chemokines might be useful by themselves to induce an immune response is not known. We hypothesized that the interferon-inducible chemokine CXCL10 could stimulate dendritic cells (DC) to mature and cross-present exogenous antigen to T cells, resulting in a Th1-type immune response. We found that injecting mice with CXCL10 together with ovalbumin (OVA) as a test antigen was sufficient to produce functional OVA-specific T cells in 7 of 10 mice. Further, using only CXCL10 and a peptide antigen derived from vaccinia virus, we were able to induce peptide-specific cytotoxic T cells in 4 of 4 mice tested. These cytotoxic T cells protected 9 of 10 mice from subsequent infectious challenge with vaccinia virus. Unlike traditional adjuvants, no side effects were observed in any of the injected mice. We conclude that CXCL10 co-administration with a variety of antigens may represent a unique strategy of inducing a protective T cell response to a number of pathogens that merits further study.

Original languageEnglish (US)
Pages (from-to)2987-2993
Number of pages7
JournalVaccine
Volume24
Issue number15
DOIs
StatePublished - Apr 5 2006

Keywords

  • Chemokine
  • Cytotoxic T cell
  • Vaccination

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