Chemogenic Subqualities of Mouthfeel

Christopher T. Simons, Amanda H. Klein, Earl Carstens

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Mouthfeel refers to the physical or textural sensations in the mouth caused by foods and beverages that are essential to the acceptability of many edible products. The sensory subqualities contributing to mouthfeel are often chemogenic in nature and include heat, burning, cooling, tingling, and numbing. These "chemesthetic" sensations are a result of the chemical activation of receptors that are associated with nerve fibers mediating pain and mechanotransduction. Each of these chemesthetic sensations in the oral cavity are transduced in the nervous system by a combination of different molecular channels/receptors expressed on trigeminal nerve fibers that innervate the mouth and tongue. The molecular profile of these channels and receptors involved in mouthfeel include many transient receptor potential channels, proton-sensitive ion channels, and potassium channels to name a few. During the last several years, studies using molecular and physiological approaches have significantly expanded and enhanced our understanding of the neurobiological basis for these chemesthetic sensations. The purpose of the current review is to integrate older and newer studies to present a comprehensive picture of the channels and receptors involved in mouthfeel. We highlight that there still continue to be important gaps in our overall knowledge on flavor integration and perception involving chemesthetic sensations, and these gaps will continue to drive future research direction and future investigation.

Original languageEnglish (US)
Article numberbjz016
Pages (from-to)281-288
Number of pages8
JournalChemical Senses
Issue number5
StatePublished - May 29 2019

Bibliographical note

Funding Information:
The authors gratefully acknowledge grant support from the National Institute of Arthritis and Musculoskeletal and Skin Diseases [AR-057194 to E.C.] and the National Institute on Drug Abuse [K01DA042902 to A.K.].

Publisher Copyright:
© 2019 The Author(s). Published by Oxford University Press. All rights reserved.


  • carbonation
  • chemesthesis
  • flavor
  • mouthfeel
  • nociceptor


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