Chemistry of carbamoyl disulfide protected derivatives of proline

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Abstract

High‐yield methods have been devised for the synthesis of a series of alkyl and aryldithiocarbonyl derivatives of the α‐imino acid proline. The carbamoyl disulfide protecting groups were rapidly and quantitatively removed under a variety of reductive conditions, suggesting their potential value for orthogonal schemes of peptide synthesis.

Original languageEnglish (US)
Pages (from-to)321-324
Number of pages4
JournalInternational Journal of Peptide and Protein Research
Volume19
Issue number3
DOIs
StatePublished - Mar 1982

Keywords

  • carbamoyl disulfides
  • orthogonal protection
  • proline
  • thiolytic cleavage

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