Abstract
High‐yield methods have been devised for the synthesis of a series of alkyl and aryldithiocarbonyl derivatives of the α‐imino acid proline. The carbamoyl disulfide protecting groups were rapidly and quantitatively removed under a variety of reductive conditions, suggesting their potential value for orthogonal schemes of peptide synthesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 321-324 |
| Number of pages | 4 |
| Journal | International Journal of Peptide and Protein Research |
| Volume | 19 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1982 |
| Externally published | Yes |
Keywords
- carbamoyl disulfides
- orthogonal protection
- proline
- thiolytic cleavage