High‐yield methods have been devised for the synthesis of a series of alkyl and aryldithiocarbonyl derivatives of the α‐imino acid proline. The carbamoyl disulfide protecting groups were rapidly and quantitatively removed under a variety of reductive conditions, suggesting their potential value for orthogonal schemes of peptide synthesis.
|Original language||English (US)|
|Number of pages||4|
|Journal||International Journal of Peptide and Protein Research|
|State||Published - Mar 1982|
- carbamoyl disulfides
- orthogonal protection
- thiolytic cleavage