Chemistry and biology of tubulysins: Antimitotic tetrapeptides with activity against drug resistant cancers

Bryan C. Murray, Michael T. Peterson, Robert A. Fecik

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations

Abstract

Covering: 2000 to 2014 Since their first report in 2000, tubulysins have sparked great interest for development as anti-cancer agents due to their exceptionally potent antiproliferative activity. Progress in the discovery and development of tubulysins, especially tubulysin conjugates, has quickly advanced despite limitations in their availability from Nature. In this Highlight, the key research on the isolation and structure determination, biosynthesis, bioactivity, structure-activity relationships (SAR), synthesis, and conjugates of tubulysins is presented. This journal is

Original languageEnglish (US)
Pages (from-to)654-662
Number of pages9
JournalNatural Product Reports
Volume32
Issue number5
DOIs
StatePublished - May 1 2015

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