Chemistry and biochemistry of the neomycins. XVII: Bioconversion of aminocyclitols to aminocyclitol antibiotics

W. Thomas Shier; Seiichiro Ogawa; Martin Hichens; Kenneth L. Rinehart

doi:10.7164/antibiotics.26.551

Chemistry and biochemistry of the neomycins. XVII: Bioconversion of aminocyclitols to aminocyclitol antibiotics

W. Thomas Shier
, Seiichiro Ogawa
, Martin Hichens
, Kenneth L. Rinehart

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Twenty-nine analogs of 2-deoxystreptamine have been tested to determine whether they are converted to antibiotics in 2-deoxystreptamine-negative mutants of Streptomyces fradiae, S. rimosus forma paromomycinus and S. kanamyceticus. Some analogs substituted at the 2-position of 2-deoxystreptamine undergo bioconversion to active antibiotics.

Original language	English (US)
Pages (from-to)	551-561
Number of pages	11
Journal	The Journal of Antibiotics
Volume	26
Issue number	10
DOIs	https://doi.org/10.7164/antibiotics.26.551
State	Published - 1973

Publisher link

10.7164/antibiotics.26.551

Find It

Find It at U of M Libraries

Cite this

@article{c01c5294b4e94276bec3c3a78db01b45,

title = "Chemistry and biochemistry of the neomycins. XVII: Bioconversion of aminocyclitols to aminocyclitol antibiotics",

abstract = "Twenty-nine analogs of 2-deoxystreptamine have been tested to determine whether they are converted to antibiotics in 2-deoxystreptamine-negative mutants of Streptomyces fradiae, S. rimosus forma paromomycinus and S. kanamyceticus. Some analogs substituted at the 2-position of 2-deoxystreptamine undergo bioconversion to active antibiotics.",

author = "Shier, \{W. Thomas\} and Seiichiro Ogawa and Martin Hichens and Rinehart, \{Kenneth L.\}",

year = "1973",

doi = "10.7164/antibiotics.26.551",

language = "English (US)",

volume = "26",

pages = "551--561",

journal = "The Journal of Antibiotics",

issn = "0021-8820",

publisher = "Springer Nature",

number = "10",

}

TY - JOUR

T1 - Chemistry and biochemistry of the neomycins. XVII

T2 - Bioconversion of aminocyclitols to aminocyclitol antibiotics

AU - Shier, W. Thomas

AU - Ogawa, Seiichiro

AU - Hichens, Martin

AU - Rinehart, Kenneth L.

PY - 1973

Y1 - 1973

N2 - Twenty-nine analogs of 2-deoxystreptamine have been tested to determine whether they are converted to antibiotics in 2-deoxystreptamine-negative mutants of Streptomyces fradiae, S. rimosus forma paromomycinus and S. kanamyceticus. Some analogs substituted at the 2-position of 2-deoxystreptamine undergo bioconversion to active antibiotics.

AB - Twenty-nine analogs of 2-deoxystreptamine have been tested to determine whether they are converted to antibiotics in 2-deoxystreptamine-negative mutants of Streptomyces fradiae, S. rimosus forma paromomycinus and S. kanamyceticus. Some analogs substituted at the 2-position of 2-deoxystreptamine undergo bioconversion to active antibiotics.

UR - https://www.scopus.com/pages/publications/0015840770

UR - https://www.scopus.com/pages/publications/0015840770#tab=citedBy

U2 - 10.7164/antibiotics.26.551

DO - 10.7164/antibiotics.26.551

M3 - Article

C2 - 4792100

AN - SCOPUS:0015840770

SN - 0021-8820

VL - 26

SP - 551

EP - 561

JO - The Journal of Antibiotics

JF - The Journal of Antibiotics

IS - 10

ER -

Chemistry and biochemistry of the neomycins. XVII: Bioconversion of aminocyclitols to aminocyclitol antibiotics

Abstract

Publisher link

Find It

Other files and links

Fingerprint

Cite this