TY - JOUR
T1 - Chemistry and biochemistry of the neomycins. XVII
T2 - Bioconversion of aminocyclitols to aminocyclitol antibiotics
AU - Shier, W. Thomas
AU - Ogawa, Seiichiro
AU - Hichens, Martin
AU - Rinehart, Kenneth L.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1973
Y1 - 1973
N2 - Twenty-nine analogs of 2-deoxystreptamine have been tested to determine whether they are converted to antibiotics in 2-deoxystreptamine-negative mutants of Streptomyces fradiae, S. rimosus forma paromomycinus and S. kanamyceticus. Some analogs substituted at the 2-position of 2-deoxystreptamine undergo bioconversion to active antibiotics.
AB - Twenty-nine analogs of 2-deoxystreptamine have been tested to determine whether they are converted to antibiotics in 2-deoxystreptamine-negative mutants of Streptomyces fradiae, S. rimosus forma paromomycinus and S. kanamyceticus. Some analogs substituted at the 2-position of 2-deoxystreptamine undergo bioconversion to active antibiotics.
UR - http://www.scopus.com/inward/record.url?scp=0015840770&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015840770&partnerID=8YFLogxK
U2 - 10.7164/antibiotics.26.551
DO - 10.7164/antibiotics.26.551
M3 - Article
C2 - 4792100
AN - SCOPUS:0015840770
SN - 0021-8820
VL - 26
SP - 551
EP - 561
JO - The Journal of Antibiotics
JF - The Journal of Antibiotics
IS - 10
ER -