Chemistry and biochemistry of the neomycins. XVII: Bioconversion of aminocyclitols to aminocyclitol antibiotics

W. Thomas Shier, Seiichiro Ogawa, Martin Hichens, Kenneth L. Rinehart

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Twenty-nine analogs of 2-deoxystreptamine have been tested to determine whether they are converted to antibiotics in 2-deoxystreptamine-negative mutants of Streptomyces fradiae, S. rimosus forma paromomycinus and S. kanamyceticus. Some analogs substituted at the 2-position of 2-deoxystreptamine undergo bioconversion to active antibiotics.

Original languageEnglish (US)
Pages (from-to)551-561
Number of pages11
JournalThe Journal of Antibiotics
Volume26
Issue number10
DOIs
StatePublished - 1973

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