Chemistry and biochemistry of the neomycins. XVI: Nthesis and bioactivity of hexa-n-benzylneomycins

Thomas Shier, Kenneth L. Rinehart

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Hexa-N-benzylneomycin and five analogs substituted on the phenyl ring have been prepared by reductive alkylation of neomycin with the appropriate benzaldehydes. Most of the six show activity, to varying degrees, against a number of microorganisms, including Staphylococcus aureus, in vitro. Little or no activity was evidenced in vivo against Staphylococcus aureus, however.

Original languageEnglish (US)
Pages (from-to)547-550
Number of pages4
JournalThe Journal of Antibiotics
Volume26
Issue number10
DOIs
StatePublished - 1973

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