Chemistry and biochemistry of the neomycins. XVI

Nthesis and bioactivity of hexa-n-benzylneomycins

Thomas Shier, Kenneth L. Rinehart

Research output: Contribution to journal › Article

5 Citations (Scopus)

Abstract

Hexa-N-benzylneomycin and five analogs substituted on the phenyl ring have been prepared by reductive alkylation of neomycin with the appropriate benzaldehydes. Most of the six show activity, to varying degrees, against a number of microorganisms, including Staphylococcus aureus, in vitro. Little or no activity was evidenced in vivo against Staphylococcus aureus, however.

Original languageEnglish (US)
Pages (from-to)547-550
Number of pages4
JournalThe Journal of Antibiotics
Volume26
Issue number10
DOIs
StatePublished - Jan 1 1973

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Neomycin
Biochemistry
Staphylococcus aureus
Benzaldehydes
Alkylation
In Vitro Techniques

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Chemistry and biochemistry of the neomycins. XVI : Nthesis and bioactivity of hexa-n-benzylneomycins. / Shier, Thomas; Rinehart, Kenneth L.

In: The Journal of Antibiotics, Vol. 26, No. 10, 01.01.1973, p. 547-550.

Research output: Contribution to journal › Article

Shier, T & Rinehart, KL 1973, 'Chemistry and biochemistry of the neomycins. XVI: Nthesis and bioactivity of hexa-n-benzylneomycins', The Journal of Antibiotics, vol. 26, no. 10, pp. 547-550. https://doi.org/10.7164/antibiotics.26.547
Shier T, Rinehart KL. Chemistry and biochemistry of the neomycins. XVI: Nthesis and bioactivity of hexa-n-benzylneomycins. The Journal of Antibiotics. 1973 Jan 1;26(10):547-550. https://doi.org/10.7164/antibiotics.26.547
Shier, Thomas ; Rinehart, Kenneth L. / Chemistry and biochemistry of the neomycins. XVI : Nthesis and bioactivity of hexa-n-benzylneomycins. In: The Journal of Antibiotics. 1973 ; Vol. 26, No. 10. pp. 547-550.
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