Chemistry and biochemistry of the neomycins. XVI: Nthesis and bioactivity of hexa-n-benzylneomycins

Thomas Shier; Kenneth L. Rinehart

doi:10.7164/antibiotics.26.547

Chemistry and biochemistry of the neomycins. XVI: Nthesis and bioactivity of hexa-n-benzylneomycins

Thomas Shier, Kenneth L. Rinehart

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Hexa-N-benzylneomycin and five analogs substituted on the phenyl ring have been prepared by reductive alkylation of neomycin with the appropriate benzaldehydes. Most of the six show activity, to varying degrees, against a number of microorganisms, including Staphylococcus aureus, in vitro. Little or no activity was evidenced in vivo against Staphylococcus aureus, however.

Original language	English (US)
Pages (from-to)	547-550
Number of pages	4
Journal	The Journal of Antibiotics
Volume	26
Issue number	10
DOIs	https://doi.org/10.7164/antibiotics.26.547
State	Published - 1973

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title = "Chemistry and biochemistry of the neomycins. XVI: Nthesis and bioactivity of hexa-n-benzylneomycins",

abstract = "Hexa-N-benzylneomycin and five analogs substituted on the phenyl ring have been prepared by reductive alkylation of neomycin with the appropriate benzaldehydes. Most of the six show activity, to varying degrees, against a number of microorganisms, including Staphylococcus aureus, in vitro. Little or no activity was evidenced in vivo against Staphylococcus aureus, however.",

author = "Thomas Shier and Rinehart, {Kenneth L.}",

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