TY - JOUR
T1 - Chemische eigenschaften und synthese‐verfahren von 3‐vinylindolen
AU - Akgün, E.
AU - Pindur, U.
PY - 1985
Y1 - 1985
N2 - Selectively functionalized 3‐vinylindoles are mostly stable compounds, which may serve as potent building blocks for anellation of the indole nucleus, in particular for synthesis of carbazole alkaloides and to obtain pharmacologically active compounds. This review describes from a great number of the permanent increasing literature of vinylheterocycles the chemical properties, the most important principles of the synthetic methods and the synthetic applications of 3‐vinylindoles. Among the synthetic methods to obtain 3‐vinylindoles the classical condensation, the Wittig‐Horner‐/Wadsworth‐Emmons‐Olefination and the recently developed Pd‐catalyzed vinylation should be considered as reliable standard methods. Depending on the special functionalization in the desired product some others methodologies are developed, so the thermolysis or the acid catalyzed ipso‐cleavage of hetarylindolylethanes for deriving 1‐hetaryl‐1‐indolylethenes.
AB - Selectively functionalized 3‐vinylindoles are mostly stable compounds, which may serve as potent building blocks for anellation of the indole nucleus, in particular for synthesis of carbazole alkaloides and to obtain pharmacologically active compounds. This review describes from a great number of the permanent increasing literature of vinylheterocycles the chemical properties, the most important principles of the synthetic methods and the synthetic applications of 3‐vinylindoles. Among the synthetic methods to obtain 3‐vinylindoles the classical condensation, the Wittig‐Horner‐/Wadsworth‐Emmons‐Olefination and the recently developed Pd‐catalyzed vinylation should be considered as reliable standard methods. Depending on the special functionalization in the desired product some others methodologies are developed, so the thermolysis or the acid catalyzed ipso‐cleavage of hetarylindolylethanes for deriving 1‐hetaryl‐1‐indolylethenes.
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U2 - 10.1002/jhet.5570220301
DO - 10.1002/jhet.5570220301
M3 - Review article
AN - SCOPUS:0022248885
SN - 0022-152X
VL - 22
SP - 585
EP - 591
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
IS - 3
ER -