Chemical Sensing Capability of MEMS Implantable Multichannel Neural Microelectrode Arrays

Matthew D. Johnson, Justin C. Williams, Matthew Holecko, Daryl R. Kipke

Research output: Contribution to journalConference articlepeer-review

8 Scopus citations

Abstract

The capability of sensing catecholamine fluctuations in the brain is useful to determine how neurostimulation - both chemical and electrical - can affect catecholamine release and uptake. Here we report preliminary results on two multichannel neural probes capable of sensing dopamine through chronoamperometry methods. With a 16-channel microelectrode array and five-channel Michigan puffer probe with a microfluidic channel, we found that a 5-cycle dip coating process of Nafion, an ion-selective polymer, optimized sensitivity to dopamine and selectivity over ascorbic acid. In addition, through fluorescent microscopy, we have shown the suitability of Nafion as a "biocompatible" material for chronically implanted microelectrode probes. These findings support the ongoing work to develop chronic implantable chemical sensors.

Original languageEnglish (US)
Pages (from-to)3333-3336
Number of pages4
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume4
StatePublished - 2003
Externally publishedYes
EventA New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico
Duration: Sep 17 2003Sep 21 2003

Keywords

  • Chemical detection
  • Dopamine
  • Drug delivery
  • Nafion
  • Neural interface

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