Chemical constituents of the fruits of Morinda citrifolia (Noni) and their antioxidant activity

Bao Ning Su, Alison D. Pawlus, Hyun Ah Jung, William J. Keller, Jerry L. McLaughlin, A. Douglas Kinghorn

Research output: Contribution to journalArticlepeer-review

143 Scopus citations

Abstract

Purification of a n-BuOH-soluble partition of the MeOH extract of Morinda citrifolia (Noni) fruits led to the isolation of two new iridoid glucosides, 6α-hydroxyadoxoside (1) and 6β,7β-epoxy-8-epi-splendoside (2), as well as 17 known compounds, americanin A (3), narcissoside (4), asperuloside, asperulosidic acid, borreriagenin, citrifolinin B epimer a, citrifolinin B epimer b, cytidine, deacetylasperuloside, dehydromethoxygaertneroside, epi-dihydrocornin, D-glucose, D-mannitol, methyl α-D-fructofuranoside, methyl β-D-fructofuranoside, nicotifloroside, and β-sitosterol 3-O-β-D-glucopyranoside. The structures of the new compounds were determined by spectroscopic data interpretation. Compound 4, borreriagenin, cytidine, deacetylasperuloside, dehydromethoxygaertneroside, epi-dihydrocornin, methyl α-D-fructofuranoside, and methyl β-D-fructofuranoside were isolated for the first time from M. citrifolia. The antioxidant activity was evaluated for all isolates in terms of both DPPH and ONOO- bioassays. The neolignan, americanin A (3), was found to be a potent antioxidant in these assays.

Original languageEnglish (US)
Pages (from-to)592-595
Number of pages4
JournalJournal of Natural Products
Volume68
Issue number4
DOIs
StatePublished - Apr 2005

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