Phytochemical investigation on Hemiphragma heterophyllum led to the isolation of two new compounds, heterophyllumin A (1) and heterophylliol (3), along with nine known compounds, (‒)-sibiricumin A (2), iridolactone (4), jatamanin A (5), dihydrocatalpolgenin (6), 25-hydroperoxycycloart-23-en-3β-ol (7), 24-methylenecycloartanol (8), (+)-pinoresinol (9), hexadec-(4Z)-enoic acid (10), and 9,12, 15-octadecatrienoic acid (11). Their structures were elucidated on the basis of detailed spectroscopic analyses and by comparison with literature data. Further, the structure of compound 3 was unambiguously confirmed by single-crystal X-ray analysis. Some of those compounds showed moderate activity in the α-glucosidase inhibition assay.
Bibliographical noteFunding Information:
This work was financially supported by the NSFC [grant number 81460535], the Natural Science Foundation of Yunnan Province [grant number Y0120160159], the Yunnan Provincial Department of Education Science Research Fund Project [grant number 2017YJS058], and the Yunnan Provincial Applied Basic Research Projects [grant number 2017FD122].
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- Hemiphragma heterophyllum
- α-glucosidase inhibitory activity
- Drugs, Chinese Herbal
- Glycoside Hydrolase Inhibitors/chemistry
- Models, Molecular
- Spiro Compounds/chemistry
- X-Ray Diffraction
- Molecular Structure
- Plant Extracts/chemistry
PubMed: MeSH publication types
- Journal Article