Abstract
Phytochemical investigation on Hemiphragma heterophyllum led to the isolation of two new compounds, heterophyllumin A (1) and heterophylliol (3), along with nine known compounds, (‒)-sibiricumin A (2), iridolactone (4), jatamanin A (5), dihydrocatalpolgenin (6), 25-hydroperoxycycloart-23-en-3β-ol (7), 24-methylenecycloartanol (8), (+)-pinoresinol (9), hexadec-(4Z)-enoic acid (10), and 9,12, 15-octadecatrienoic acid (11). Their structures were elucidated on the basis of detailed spectroscopic analyses and by comparison with literature data. Further, the structure of compound 3 was unambiguously confirmed by single-crystal X-ray analysis. Some of those compounds showed moderate activity in the α-glucosidase inhibition assay.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 551-558 |
| Number of pages | 8 |
| Journal | Journal of Asian Natural Products Research |
| Volume | 21 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 3 2019 |
Bibliographical note
Funding Information:This work was financially supported by the NSFC [grant number 81460535], the Natural Science Foundation of Yunnan Province [grant number Y0120160159], the Yunnan Provincial Department of Education Science Research Fund Project [grant number 2017YJS058], and the Yunnan Provincial Applied Basic Research Projects [grant number 2017FD122].
Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
Keywords
- Hemiphragma heterophyllum
- Scrophulariaceae
- iridoids
- sesquineolignans
- α-glucosidase inhibitory activity
- Drugs, Chinese Herbal
- Glycoside Hydrolase Inhibitors/chemistry
- Models, Molecular
- Iridoids/chemistry
- Spiro Compounds/chemistry
- X-Ray Diffraction
- Scrophulariaceae/chemistry
- Lignans/chemistry
- Molecular Structure
- Plant Extracts/chemistry
PubMed: MeSH publication types
- Journal Article