Chemical constituents from the whole herb of Hemiphragma heterophyllum

Jia Meng Dai, Yan Hong Li, Xiao Yun Pu, Cui Yang, Jing Xian Sun, R. R Ruan, Xiao Nian Li, Kai Tian, Xiang Zhong Huang

Research output: Contribution to journalArticle

Abstract

Phytochemical investigation on Hemiphragma heterophyllum led to the isolation of two new compounds, heterophyllumin A (1) and heterophylliol (3), along with nine known compounds, (‒)-sibiricumin A (2), iridolactone (4), jatamanin A (5), dihydrocatalpolgenin (6), 25-hydroperoxycycloart-23-en-3β-ol (7), 24-methylenecycloartanol (8), (+)-pinoresinol (9), hexadec-(4Z)-enoic acid (10), and 9,12, 15-octadecatrienoic acid (11). Their structures were elucidated on the basis of detailed spectroscopic analyses and by comparison with literature data. Further, the structure of compound 3 was unambiguously confirmed by single-crystal X-ray analysis. Some of those compounds showed moderate activity in the α-glucosidase inhibition assay. (Figure presented.).

Original languageEnglish (US)
Pages (from-to)551-558
Number of pages8
JournalJournal of Asian Natural Products Research
Volume21
Issue number6
DOIs
StatePublished - Jun 3 2019

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Glucosidases
Acids
X ray analysis
Phytochemicals
Assays
X-Rays
Single crystals
pinoresinol
sibiricumin A
iridolactone

Keywords

  • Hemiphragma heterophyllum
  • Scrophulariaceae
  • iridoids
  • sesquineolignans
  • α-glucosidase inhibitory activity

Cite this

Chemical constituents from the whole herb of Hemiphragma heterophyllum. / Dai, Jia Meng; Li, Yan Hong; Pu, Xiao Yun; Yang, Cui; Sun, Jing Xian; Ruan, R. R; Li, Xiao Nian; Tian, Kai; Huang, Xiang Zhong.

In: Journal of Asian Natural Products Research, Vol. 21, No. 6, 03.06.2019, p. 551-558.

Research output: Contribution to journalArticle

Dai, JM, Li, YH, Pu, XY, Yang, C, Sun, JX, Ruan, RR, Li, XN, Tian, K & Huang, XZ 2019, 'Chemical constituents from the whole herb of Hemiphragma heterophyllum', Journal of Asian Natural Products Research, vol. 21, no. 6, pp. 551-558. https://doi.org/10.1080/10286020.2018.1504025
Dai, Jia Meng ; Li, Yan Hong ; Pu, Xiao Yun ; Yang, Cui ; Sun, Jing Xian ; Ruan, R. R ; Li, Xiao Nian ; Tian, Kai ; Huang, Xiang Zhong. / Chemical constituents from the whole herb of Hemiphragma heterophyllum. In: Journal of Asian Natural Products Research. 2019 ; Vol. 21, No. 6. pp. 551-558.
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