Chemical characterization of smokeless tobacco products and relevant exposures in users

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Smokeless tobacco (ST) products are characterized by enormous diversity of types and formulations. Many are made with complex mixtures of ingredients and processes that can modify tobacco addictiveness, toxicity, and carcinogenicity. Data on biomarkers of exposure provide important information on the intake of chemical toxicants and carcinogens from the use of ST. Therefore, chemical characterization of ST products and related exposures in users is key to understanding the toxic and carcinogenic potential of ST and development of preventive measures. This chapter provides an overview of sources, levels, and variation of harmful constituents in ST products, relevant biomarkers to assess users' exposure to these constituents, and analytical methods for the measurement of constituents and biomarkers in ST studies. Variations in the levels of key harmful constituents across ST products and the impact of these variations on related exposures are emphasized, and policy implications of such variations are discussed.

Original languageEnglish (US)
Title of host publicationSmokeless Tobacco Products
Subtitle of host publicationCharacteristics, Usage, Health Effects, and Regulatory Implications
Number of pages30
ISBN (Electronic)9780128181591
ISBN (Print)9780128181584
StatePublished - Jan 21 2020


  • Carcinogens
  • Nicotine addiction
  • Polycyclic aromatic hydrocarbons (PAH)
  • Smokeless tobacco formulation
  • Tobacco-specific N-nitrosamines (TSNA)
  • Toxicity

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