Chemical and physical factors influencing methicillin resistance of Staphylococcus aureus and Staphylococcus epidermidis.

L. D. Sabath

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Seven physical or chemical factors have been demonstrated to increase or decrease the proportion of cells expressing methicillin resistance in populations of methicillin resistant S. aureus and S. epidermidis. These factors are: temperature, visible light, osmolality, pH, chelating agents, trace metals and the presence of beta-lactam antibiotics in the medium. All of these factors were first noted in S. aureus, but it now appears that they also influence the expression of methicillin resistance in S. epidermidis. Although many of the studies of these factors to date have been directed to techniques for detecting resistance, it is quite possible that many (or possibly all) of these factors are important clues to the mechanism of this resistance and its operation in human infections.
Original languageUndefined/Unknown
Pages (from-to)47-51
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Issue numberSuppl. C
StatePublished - 1977


  • antibiotic resistance
  • drug resistance
  • in vitro study
  • microorganism
  • Staphylococcus aureus
  • Staphylococcus epidermidis
  • theoretical study
  • 6 aminopenicillanic acid
  • 7 aminocephalosporanic acid
  • cefaloridine
  • cefalotin
  • meticillin

Cite this