Chelator-free synthesis of a dual-modality PET/MRI agent

Feng Chen; Paul A. Ellison; Christina M. Lewis; Hao Hong; Yin Zhang; Sixiang Shi; Reinier Hernandez; M. Elizabeth Meyerand; Todd E. Barnhart; Weibo Cai

doi:10.1002/anie.201306306

Chelator-free synthesis of a dual-modality PET/MRI agent

Feng Chen, Paul A. Ellison, Christina M. Lewis, Hao Hong, Yin Zhang, Sixiang Shi, Reinier Hernandez, M. Elizabeth Meyerand, Todd E. Barnhart, Weibo Cai

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

Old technique, new application: A simple and efficient chelator-free strategy for the synthesis of a novel dual-modality PET/MRI agent has been developed. Labeling of radioarsenic (*As^III and *As ^V,*=71, 72, 74, 76) at the surface of superparamagnetic iron oxide nanoparticles (SPIONs) resulted in*As-SPIONs that can be used for simultaneous PET/MRI in cancer diagnosis, lymph-node mapping, and potentially for internal radiotherapy.

Original language	English (US)
Pages (from-to)	13319-13323
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	50
DOIs	https://doi.org/10.1002/anie.201306306
State	Published - Dec 9 2013
Externally published	Yes

Keywords

arsenic
cancer
magnetic resonance imaging
positron emission tomography
radiochemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201306306

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title = "Chelator-free synthesis of a dual-modality PET/MRI agent",

abstract = "Old technique, new application: A simple and efficient chelator-free strategy for the synthesis of a novel dual-modality PET/MRI agent has been developed. Labeling of radioarsenic (*AsIII and *As V,*=71, 72, 74, 76) at the surface of superparamagnetic iron oxide nanoparticles (SPIONs) resulted in*As-SPIONs that can be used for simultaneous PET/MRI in cancer diagnosis, lymph-node mapping, and potentially for internal radiotherapy.",

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day = "9",

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AU - Chen, Feng

AU - Ellison, Paul A.

AU - Lewis, Christina M.

AU - Hong, Hao

AU - Zhang, Yin

AU - Shi, Sixiang

AU - Hernandez, Reinier

AU - Meyerand, M. Elizabeth

AU - Barnhart, Todd E.

AU - Cai, Weibo

PY - 2013/12/9

Y1 - 2013/12/9

N2 - Old technique, new application: A simple and efficient chelator-free strategy for the synthesis of a novel dual-modality PET/MRI agent has been developed. Labeling of radioarsenic (*AsIII and *As V,*=71, 72, 74, 76) at the surface of superparamagnetic iron oxide nanoparticles (SPIONs) resulted in*As-SPIONs that can be used for simultaneous PET/MRI in cancer diagnosis, lymph-node mapping, and potentially for internal radiotherapy.

AB - Old technique, new application: A simple and efficient chelator-free strategy for the synthesis of a novel dual-modality PET/MRI agent has been developed. Labeling of radioarsenic (*AsIII and *As V,*=71, 72, 74, 76) at the surface of superparamagnetic iron oxide nanoparticles (SPIONs) resulted in*As-SPIONs that can be used for simultaneous PET/MRI in cancer diagnosis, lymph-node mapping, and potentially for internal radiotherapy.

KW - arsenic

KW - cancer

KW - magnetic resonance imaging

KW - positron emission tomography

KW - radiochemistry

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ER -

Chelator-free synthesis of a dual-modality PET/MRI agent

Abstract

Keywords

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