Checkpoints controlling mitosis

Duncan J. Clarke, Juan F. Giménez-Abián

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Each year many reviews deal with checkpoint control. Here we discuss checkpoint pathways that control mitosis. We address four checkpoint systems in depth: budding yeast DNA damage, the DNA replication checkpoint, the spindle assembly checkpoint and the mammalian G2 topoisomerase II-dependent checkpoint. A main focus of the review is the organization of these checkpoint pathways. Recent work has elucidated the order-of-function of several checkpoint components, and has revealed that the S phase, DNA damage and spindle assembly checkpoints each have at least two parallel branches. These steps forward have largely come from kinetic studies of checkpoint-defective mutants. (C) 2000 John Wiley and Sons, Inc.

Original languageEnglish (US)
Pages (from-to)351-363
Number of pages13
Issue number4
StatePublished - 2000


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