Checkpoints controlling mitosis

Duncan J. Clarke, Juan F. Giménez-Abián

Research output: Contribution to journalReview article

84 Scopus citations

Abstract

Each year many reviews deal with checkpoint control. Here we discuss checkpoint pathways that control mitosis. We address four checkpoint systems in depth: budding yeast DNA damage, the DNA replication checkpoint, the spindle assembly checkpoint and the mammalian G2 topoisomerase II-dependent checkpoint. A main focus of the review is the organization of these checkpoint pathways. Recent work has elucidated the order-of-function of several checkpoint components, and has revealed that the S phase, DNA damage and spindle assembly checkpoints each have at least two parallel branches. These steps forward have largely come from kinetic studies of checkpoint-defective mutants. (C) 2000 John Wiley and Sons, Inc.

Original languageEnglish (US)
Pages (from-to)351-363
Number of pages13
JournalBioEssays
Volume22
Issue number4
DOIs
StatePublished - 2000

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