Characterizing the role of fibroblast migration in an in vitro assay of wound contraction

Bruce A. Bromberek, Robert T Tranquillo

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Cells in Fibroblast-Populated Microsphere (FPM) Wound assay, in contrast to the FPM Traction assay, can exhibit circumferential orientation due to a contact guidance response: the FPM compaction is inhomogeneous due to the imposed non-uniform initial cell distribution, inducing circumferential orientation of the fibrin fibrils. The assay, in this manner, is in fact a model system for studying a basic morphogenetic process. Accordingly, the dependence of FPM compaction and cell distribution on initial cell concentration and FPM dimensions are thus experimentally described and discussed in the context of an anisotropic biphasic model for cell-matrix mechanical interactions.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Number of pages2
StatePublished - Jan 1 1995
EventProceedings of the 1995 Bioengineering Conference - Beever Creek, CO, USA
Duration: Jun 28 1995Jul 2 1995


OtherProceedings of the 1995 Bioengineering Conference
CityBeever Creek, CO, USA


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