Characterizing the memory of the GAL regulatory network in Saccharomyces cerevisiae

Vishwesh V. Kulkarni, Venkatesh Kareenhalli, Ganesh A. Viswananthan, Marc Riedel

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Genetic regulatory networks respond dynamically to perturbations in the intracellular and extracellular environments of an organism. The GAL system in the yeast Saccharomyces cerevisiae has evolved to utilize galactose as an alternative carbon and energy source, in the absence of glucose in the environment. We present a dynamic model for GAL system in Saccharomyces cerevisiae, which includes a novel mechanism for Gal3p activation upon induction with galactose. The modification enables the model to simulate the experimental observation that in absence of galactose, oversynthesis of Gal3p can also induce the GAL system. We then characterize the memory of the GAL system as the domain of attraction of the steady states.

Original languageEnglish (US)
Pages (from-to)97-104
Number of pages8
JournalSystems and Synthetic Biology
Issue number3-4
StatePublished - Dec 2011

Bibliographical note

Funding Information:
Acknowledgments This research is supported, in parts, by NSF CAREER Award 0845650 and by Department of Science and Technology India.


  • Cellular memory
  • Domain of attraction
  • GAL system
  • ODE model
  • Saccharomyces cerevisiae


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