Characterization of thymocytes expressing the common acute lymphoblastic leukemia antigen

Steven M.L. Neudorf, Tucker W. Lebien, John H. Kersey

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

We studied the relationship between CALLA + thymocytes and two known markers of T-lymphocyte differentiation, Tdt and the sheep erythrocyte receptor. Thymocytes were studied using double fluorochrome analysis (with monoclonal anti-CALLA antibody and anti-Tdt) before and after E rosette separation. We found that approx. 4% of unseparated thymocytes were CALLA + and that most CALLA + cells were also Tdt+. After E rosettes separation CALLA + Tdt + cells were found mostly in the ER- fraction (20% of ER- cells) while only 1.0% of ER + cells were CALLA +. The expression of CALLA on ER- Tdt + thymocytes suggests that CALLA may defined cells early in T-cell differentiation.

Original languageEnglish (US)
Pages (from-to)173-175,177-179
JournalLeukemia research
Volume8
Issue number2
DOIs
StatePublished - 1984

Keywords

  • Common acute lymphoblastic leukemia antigen
  • prothymocyte
  • terminal deoxynucleotidyl transferase

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