Characterization of therapeutic coatings on medical devices

Klaus Wormuth

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Therapeutic coatings on medical devices such as catheters, guide wires, and stents improve biocompatibility by favorably altering the chemical nature of the device/tissue or device/blood interface. Such coatings often minimize tissue damage (reduce friction), decrease chances for blood clot formation (prevent platelet adsorption), and improve the healing response (deliver drugs). Confocal Raman microscopy provides valuable information about biomedical coatings by, for example, facilitating the measurement of the thickness and swelling of frictionreducing hydrogel coatings on catheters and by determining the distribution of drug within a polymer-based drug-eluting coatings on stents. This chapter explores the application of Raman microscopy to the imaging of thin coatings of cross-linked poly(vinyl pyrrolidone) gels, parylene films, mixtures of dexamethasone with various polymethacrylates, and mixtures of rapamycin with hydrolysable (biodegradable) poly(lactide-co-glycolide) polymers. Raman microscopy measures the thickness and swelling of coatings, reveals the degree of mixing of drug and polymer, senses the hydrolysis of biodegradable polymers, and determines the polymorphic forms of drug present within thin therapeutic coatings on medical devices.

Original languageEnglish (US)
Title of host publicationConfocal Raman Microscopy
EditorsThomas Dieing, Jan Toporski, Olaf Hollricher
Pages203-223
Number of pages21
DOIs
StatePublished - Dec 1 2010

Publication series

NameSpringer Series in Optical Sciences
Volume158
ISSN (Print)0342-4111
ISSN (Electronic)1556-1534

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