Abstract
The primary solution degradation products of the antiulcer drug etintidine (1,N″‐cyano‐N‐[2‐[[(5‐methyl‐1H‐imidazol‐4‐yl)methyl]thio]ethyl]‐N′‐2‐propynylguanidine) were determined to be the guanyl urea 2, the guanidine 3, the amine 4a, and the cyanoamine 4b. These products resulted from nitrile hydrolysis and/or intramolecular cyclization of the guanidino and propargyl groups. The amine 4a was found to be a predominant degradation product in aqueous media of pH 4–7 at 70 ± 0.2°C.
Original language | English (US) |
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Pages (from-to) | 21-24 |
Number of pages | 4 |
Journal | Journal of Pharmaceutical Sciences |
Volume | 78 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1989 |
Bibliographical note
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