Characterization of the PEG layer of sterically stabilized liposomes: A SAXS study

Z. Varga, A. Wacha, U. Vainio, J. Gummel, A. Bóta

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Synchrotron small-angle X-ray scattering analysis of the bilayer structure of a pharmacologically relevant sterically stabilized liposome system is presented. Describing the electron density profile of the bilayer with the superposition of Gaussian functions, the contribution of the poly(ethylene glycol) (PEG) layers to the total electron density was identified. The changes in the thickness of the PEG layer as well as the distribution of the PEG chains among the outer and inner leaflets of the bilayers were followed by changing the molar ratio of the PEG-lipid and the molar weight of the PEG molecule.

Original languageEnglish (US)
Pages (from-to)387-392
Number of pages6
JournalChemistry and Physics of Lipids
Volume165
Issue number4
DOIs
StatePublished - May 1 2012

Keywords

  • Liposomes
  • Poly(ethylene glycol)
  • Small-angle X-ray scattering
  • Sterical stabilization
  • Structural characterization

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