Characterization of the PEG layer of sterically stabilized liposomes: A SAXS study

Z. Varga, A. Wacha, U. Vainio, J. Gummel, A. Bóta

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Synchrotron small-angle X-ray scattering analysis of the bilayer structure of a pharmacologically relevant sterically stabilized liposome system is presented. Describing the electron density profile of the bilayer with the superposition of Gaussian functions, the contribution of the poly(ethylene glycol) (PEG) layers to the total electron density was identified. The changes in the thickness of the PEG layer as well as the distribution of the PEG chains among the outer and inner leaflets of the bilayers were followed by changing the molar ratio of the PEG-lipid and the molar weight of the PEG molecule.

Original languageEnglish (US)
Pages (from-to)387-392
Number of pages6
JournalChemistry and Physics of Lipids
Volume165
Issue number4
DOIs
StatePublished - May 2012

Bibliographical note

Funding Information:
This work was supported by the Hungarian Scientific Research Fund (OTKA, Hungary) and the National Innovation Office (NIH, Hungary) under grant agreement CNK-81056 . The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007–2013) under grant agreement no 226716 at DESY/HASYLAB. We are grateful to the European Synchrotron Radiation Facility for provision of beam time at ID02 (proposal no. SC-3269).

Keywords

  • Liposomes
  • Poly(ethylene glycol)
  • Small-angle X-ray scattering
  • Sterical stabilization
  • Structural characterization

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