Characterization of the human cellular immune response to purified group A streptococcal blastogen A

W. E. Regelmann, E. D. Gray, L. W. Wannamaker

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The human mononuclear cell response to purified extracellular streptococcal protein, blastogen A, was compared to the response of these cells to PHA and tetanus antigen. Blastogen A induced peak uptake of thymidine during day 6 of tissue culture whereas PHA induced peak uptake during day 5 and tetanus during day 8. Like PHA, blastogen A transformed human umbilical cord lymphocytes and those of nonimmune animals. Also like PHA, blastogen A transformed primarily T lymphocytes. However, unlike PHA, the ability of T lymphocytes to respond to blastogen A was almost completely dependent on the presence of viable non-T lymphocytes. Monocytes were not as effective in facilitating the response to blastogen A as they were for PHA. Thus, blastogen A behaves most like a polyclonal T lymphocyte mitogen, although the degree of dependence of the transformation response on the presence of non-T lymphocytes is much greater than that of PHA.

Original languageEnglish (US)
Pages (from-to)1631-1636
Number of pages6
JournalJournal of Immunology
Volume128
Issue number4
StatePublished - Jan 1 1982

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