Characterization of subcellular localization and Ca2+ modulation of calsenilin/DREAM/KChIP3

Ha Na Woo; Jae Woong Chang; Yun Hyung Choi; A. Ryeong Gwon; Yong Keun Jung; Dong Gyu Jo

doi:10.1097/WNR.0b013e3283089209

Characterization of subcellular localization and Ca2+ modulation of calsenilin/DREAM/KChIP3

Ha Na Woo, Jae Woong Chang, Yun Hyung Choi, A. Ryeong Gwon, Yong Keun Jung, Dong Gyu Jo

Biochemistry, Molecular Biology, and Biophysics (CBS)

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Earlier reports found that calsenilin is a transcriptional repressor or a subunit of plasma membrane channel, and indicated that calsenilin was present in the nucleus or plasma membrane. Immunohistochemical and subcellular fractionation analysis, however, revealed that calsenilin/DREAM/KChIP3 was distributed throughout the cytoplasm of SK-N-BE2(C), Jurkat, and HeLa cells. In addition, the expression of calsenilin suppressed the ATP-induced increase in intracellular Ca concentrations. By increase in intracellular calcium concentration, calsenilin was translocated into the nucleus.

Original language	English (US)
Pages (from-to)	1193-1197
Number of pages	5
Journal	Neuroreport
Volume	19
Issue number	12
DOIs	https://doi.org/10.1097/WNR.0b013e3283089209
State	Published - Aug 6 2008

Keywords

Calcium
Calsenilin/DREAM/KChIP3
Subcellular localization

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10.1097/WNR.0b013e3283089209

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title = "Characterization of subcellular localization and Ca2+ modulation of calsenilin/DREAM/KChIP3",

abstract = "Earlier reports found that calsenilin is a transcriptional repressor or a subunit of plasma membrane channel, and indicated that calsenilin was present in the nucleus or plasma membrane. Immunohistochemical and subcellular fractionation analysis, however, revealed that calsenilin/DREAM/KChIP3 was distributed throughout the cytoplasm of SK-N-BE2(C), Jurkat, and HeLa cells. In addition, the expression of calsenilin suppressed the ATP-induced increase in intracellular Ca concentrations. By increase in intracellular calcium concentration, calsenilin was translocated into the nucleus.",

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author = "Woo, \{Ha Na\} and Chang, \{Jae Woong\} and Choi, \{Yun Hyung\} and Gwon, \{A. Ryeong\} and Jung, \{Yong Keun\} and Jo, \{Dong Gyu\}",

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T1 - Characterization of subcellular localization and Ca2+ modulation of calsenilin/DREAM/KChIP3

AU - Woo, Ha Na

AU - Chang, Jae Woong

AU - Choi, Yun Hyung

AU - Gwon, A. Ryeong

AU - Jung, Yong Keun

AU - Jo, Dong Gyu

PY - 2008/8/6

Y1 - 2008/8/6

N2 - Earlier reports found that calsenilin is a transcriptional repressor or a subunit of plasma membrane channel, and indicated that calsenilin was present in the nucleus or plasma membrane. Immunohistochemical and subcellular fractionation analysis, however, revealed that calsenilin/DREAM/KChIP3 was distributed throughout the cytoplasm of SK-N-BE2(C), Jurkat, and HeLa cells. In addition, the expression of calsenilin suppressed the ATP-induced increase in intracellular Ca concentrations. By increase in intracellular calcium concentration, calsenilin was translocated into the nucleus.

AB - Earlier reports found that calsenilin is a transcriptional repressor or a subunit of plasma membrane channel, and indicated that calsenilin was present in the nucleus or plasma membrane. Immunohistochemical and subcellular fractionation analysis, however, revealed that calsenilin/DREAM/KChIP3 was distributed throughout the cytoplasm of SK-N-BE2(C), Jurkat, and HeLa cells. In addition, the expression of calsenilin suppressed the ATP-induced increase in intracellular Ca concentrations. By increase in intracellular calcium concentration, calsenilin was translocated into the nucleus.

KW - Calcium

KW - Calsenilin/DREAM/KChIP3

KW - Subcellular localization

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AN - SCOPUS:51649097735

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JO - Neuroreport

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IS - 12

ER -

Characterization of subcellular localization and Ca2+ modulation of calsenilin/DREAM/KChIP3

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